| Gene Information | |
|---|---|
| Gene Name | WRAP73 |
| Organism | Homo sapiens (Human) |
| Gene Length | 460 |
| Protein Names | WD repeat-containing protein WRAP73 (WD repeat-containing protein 8) (WD repeat-containing protein antisense to TP73 gene) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000116213 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9P2S5 |
| Gene Card | WRAP73 |
| Uniprot ID | Q9P2S5 |
| Pfam | PF00400 |
| In ASD | no |
| Allosteric Prediction | no (-1.337952311) |
| Ortholog in Animals | Alpaca_ WRAP73 ( ortholog_one2one ) Dog_ WRAP73 ( ortholog_one2one ) GuineaPig_ WRAP73 ( ortholog_one2one ) Macaque_ WRAP73 ( ortholog_one2many ) Mouse_ Wrap73 ( ortholog_one2one ) Pig_ WRAP73 ( ortholog_one2one ) Rat_ Wrap73 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Predominant expression in heart, brain, liver, thymus, prostate, and testis, and barely detectable expression in lung. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2760320 rs16823940 |
| Subcellular location [CC] | Cytoplasm {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:26545777, ECO:0000269|PubMed:26675238}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:26675238}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:26675238}. Note=Enriched in the proximal end of the mother centriole (PubMed:26545777). During ciliogenesis also associated with the basal body of the adjacent centriole (PubMed:26675238). {ECO:0000269|PubMed:26545777, ECO:0000269|PubMed:26675238}. |
| Mouse PG classification | NA |
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