| Gene Information | |
|---|---|
| Gene Name | PAP |
| Organism | Homo sapiens (Human) |
| Gene Length | 175 |
| Protein Names | Regenerating islet-derived protein 3-alpha (REG-3-alpha) (Hepatointestinal pancreatic protein) (HIP/PAP) (Human proislet peptide) (Pancreatitis-associated protein 1) (Regenerating islet-derived protein III-alpha) (Reg III-alpha) [Cleaved into: Regenerating islet-derived protein 3-alpha 16.5 kDa form; Regenerating islet-derived protein 3-alpha 15 kDa form] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q06141 |
| Gene Card | REG3A |
| Uniprot ID | Q06141 |
| Pfam | PF00059 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in epidermal keratinocytes of psoriasis patients (at protein level). Constitutively expressed in intestine. Low expression is found in healthy pancreas. Overexpressed during the acute phase of pancreatitis and in some patients with chronic pancreatitis. {ECO:0000269|PubMed:1469087, ECO:0000269|PubMed:22727489}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1UV0 (X-ray 1.78A ) 2GO0 (NMR - ) 4MTH (X-ray 1.47A ) |
| DBSNP | NA |
| Subcellular location [CC] | Secreted. Note=Found in the apical region of pancreatic acinar cells. |
| Mouse PG classification | NA |
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