| Gene Information | |
|---|---|
| Gene Name | BECN1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 450 |
| Protein Names | Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa] |
| Target Name | beclin-1 |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000126581 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q14457 |
| Gene Card | BECN1 |
| Uniprot ID | Q14457 |
| Pfam | PF04111; PF17675; PF15285 |
| In ASD | no |
| Allosteric Prediction | yes (0.695967513) |
| Ortholog in Animals | Alpaca_ BECN1 ( ortholog_one2one ) Dog_ BECN1 ( ortholog_one2one ) GuineaPig_ BECN1 ( ortholog_one2one ) Macaque_ BECN1 ( ortholog_one2one ) Mouse_ Becn1 ( ortholog_one2one ) Pig_ BECN1 ( ortholog_one2one ) Rat_ Becn1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | BECN2 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 2P1L (X-ray 2.50A ) 2PON (NMR - ) 3DVU (X-ray 2.50A ) 4DDP (X-ray 1.55A ) 4MI8 (X-ray 2.10A ) 5EFM (X-ray 1.95A ) 5HHE (X-ray 1.46A ) 5VAU (X-ray 1.75A ) 5VAX (X-ray 2.00A ) 5VAY (X-ray 1.80A ) 6DCN (X-ray 2.44A ) 6DCO (X-ray 2.20A ) 6HOI (X-ray 1.14A ) 6HOJ (X-ray 1.51A ) 6HOK (X-ray 1.61A ) 7BL1 (EM 9.80A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:19713971, ECO:0000269|PubMed:21364619, ECO:0000269|PubMed:22498477}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:19050071}; Peripheral membrane protein {ECO:0000269|PubMed:19050071}. Endosome membrane {ECO:0000269|PubMed:23878393}; Peripheral membrane protein {ECO:0000269|PubMed:23878393}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:23878393}; Peripheral membrane protein {ECO:0000269|PubMed:23878393}. Mitochondrion membrane {ECO:0000269|PubMed:23878393}; Peripheral membrane protein {ECO:0000269|PubMed:23878393}. Endosome {ECO:0000250|UniProtKB:O88597}. Cytoplasmic vesicle, autophagosome {ECO:0000305}. Note=Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity). {ECO:0000250|UniProtKB:O88597, ECO:0000269|PubMed:19050071}.; [Beclin-1-C 35 kDa]: Mitochondrion {ECO:0000269|PubMed:21364619, ECO:0000269|PubMed:26263979}. Nucleus {ECO:0000269|PubMed:19713971}. Cytoplasm {ECO:0000269|PubMed:19713971}.; [Beclin-1-C 37 kDa]: Mitochondrion {ECO:0000250|UniProtKB:O88597}. |
| Mouse PG classification | NA |
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