| Gene Information | |
|---|---|
| Gene Name | PAN2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1202 |
| Protein Names | PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (EC 3.1.13.4) (Inactive ubiquitin carboxyl-terminal hydrolase 52) (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 2) (PAN deadenylation complex subunit 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000135473 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q504Q3 |
| Gene Card | PAN2 |
| Uniprot ID | Q504Q3 |
| Pfam | PF00929; PF13423 |
| In ASD | no |
| Allosteric Prediction | yes (0.132016431) |
| Ortholog in Animals | Alpaca_ PAN2 ( ortholog_one2one ) Dog_ PAN2 ( ortholog_one2one ) GuineaPig_ PAN2 ( ortholog_one2one ) Macaque_ PAN2 ( ortholog_one2one ) Mouse_ Pan2 ( ortholog_one2one ) Pig_ PAN2 ( ortholog_one2one ) Rat_ Pan2 ( ortholog_one2one ) Rabbit_ PAN2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002990(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs11558139 rs1918496 rs1330054285 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:16284618}. Cytoplasm, P-body {ECO:0000255|HAMAP-Rule:MF_03182, ECO:0000269|PubMed:18625844, ECO:0000269|PubMed:23398456}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03182, ECO:0000269|PubMed:16284618}. Note=Shuttles between nucleus and cytoplasm. {ECO:0000255|HAMAP-Rule:MF_03182, ECO:0000269|PubMed:16284618}. |
| Mouse PG classification | NA |
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