| Gene Information | |
|---|---|
| Gene Name | PAM |
| Organism | Homo sapiens (Human) |
| Gene Length | 973 |
| Protein Names | Peptidyl-glycine alpha-amidating monooxygenase (PAM) [Includes: Peptidylglycine alpha-hydroxylating monooxygenase (PHM) (EC 1.14.17.3); Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (EC 4.3.2.5) (Peptidylamidoglycolate lyase) (PAL)] |
| Target Name | peptidyl-glycine alpha-amidating monooxygenase |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000145730 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P19021 |
| Gene Card | PAM |
| Uniprot ID | P19021 |
| Pfam | PF03712; PF01082; PF01436 |
| In ASD | no |
| Allosteric Prediction | yes (0.555144739) |
| Ortholog in Animals | Alpaca_ PAM ( ortholog_one2one ) Dog_ PAM ( ortholog_one2one ) GuineaPig_ PAM ( ortholog_one2one ) Macaque_ PAM ( ortholog_one2one ) Mouse_ Pam ( ortholog_one2one ) Pig_ PAM ( ortholog_one2one ) Rat_ Pam ( ortholog_one2one ) Rabbit_ PAM ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2230458 |
| Subcellular location [CC] | Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:P10731}; Single-pass membrane protein {ECO:0000250|UniProtKB:P10731}. Note=Secretory granules. {ECO:0000250|UniProtKB:P10731}.; [Isoform 1]: Membrane; Single-pass type I membrane protein.; [Isoform 2]: Membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted. Note=Secreted from secretory granules.; [Isoform 4]: Secreted. Note=Secreted from secretory granules. |
| Mouse PG classification | NA |
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