| Gene Information | |
|---|---|
| Gene Name | PAM |
| Organism | Homo sapiens (Human) |
| Gene Length | 4678 |
| Protein Names | E3 ubiquitin-protein ligase MYCBP2 (EC 2.3.2.33) (Myc-binding protein 2) (Protein associated with Myc) |
| Target Name | peptidyl-glycine alpha-amidating monooxygenase |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000145730 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | NA |
| Gene Card | MYCBP2 |
| Uniprot ID | O75592 |
| Pfam | PF03256; PF08005; PF00415; PF08239; PF13639 |
| In ASD | no |
| Allosteric Prediction | yes (0.555144739) |
| Ortholog in Animals | Alpaca_ PAM ( ortholog_one2one ) Dog_ PAM ( ortholog_one2one ) GuineaPig_ PAM ( ortholog_one2one ) Macaque_ PAM ( ortholog_one2one ) Mouse_ Pam ( ortholog_one2one ) Pig_ PAM ( ortholog_one2one ) Rat_ Pam ( ortholog_one2one ) Rabbit_ PAM ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in all tissues examined, expression is exceptionally abundant in brain and thymus. Colocalizes with TSC1 and TSC2 along the neurites and in the growth cones. Highly expressed in peripheral and central neurons. Colocalized with TSC1 in one of the filopodial extensions at the tip of a growth cone. {ECO:0000269|PubMed:9689053}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5O6C (X-ray 1.75A ) 6T7F (X-ray 2.58A ) |
| DBSNP | rs35887505 rs9574002 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:26304119, ECO:0000269|PubMed:9689053}. Cell projection, axon {ECO:0000250|UniProtKB:Q7TPH6}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q7TPH6}. Note=Localizes to axon shafts and associates with microtubule cytoskeleton (By similarity). Translocates to the nucleus following interaction with sumoylated RANGAP1 (PubMed:26304119). {ECO:0000250|UniProtKB:Q7TPH6, ECO:0000269|PubMed:26304119}. |
| Mouse PG classification | NA |
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