Gene Information
Gene NamePALS1
OrganismHomo sapiens (Human)
Gene Length675
Protein NamesProtein PALS1 (MAGUK p55 subfamily member 5) (Membrane protein, palmitoylated 5) (Protein associated with Lin-7 1)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000072415 )
Evolutionary StageEumetazoa
AlphaFoldDBQ8N3R9
Gene CardPALS1
Uniprot IDQ8N3R9
PfamPF00625; PF02828; PF09060; PF00595; PF07653
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsAlpaca_ PALS1 ( ortholog_one2one )
Dog_ PALS1 ( ortholog_one2one )
GuineaPig_ PALS1 ( ortholog_one2one )
Macaque_ PALS1 ( ortholog_one2one )
Mouse_ Pals1 ( ortholog_one2one )
Pig_ PALS1 ( ortholog_one2one )
Rat_ Mpp5 ( ortholog_one2one )
Rabbit_ PALS1 ( ortholog_one2one )
OhnologsNA
ParalogsMPP3, MPP7, MPP2, CASK, PALS2, MPP1, MPP4
TissueNA
Tissue SpecificityExpressed at the outer limiting membrane in the retina (at protein level) (PubMed:15914641, PubMed:15558731, PubMed:16519681, PubMed:17584769). Expressed in T lymphocytes (at protein level) (PubMed:21479189). Expressed in the kidney (at protein level) (PubMed:17584769). {ECO:0000269|PubMed:15558731, ECO:0000269|PubMed:15914641, ECO:0000269|PubMed:16519681, ECO:0000269|PubMed:17584769, ECO:0000269|PubMed:21479189}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1Y76  (NMR  -  )  3UIT  (X-ray  2.05A  )  4UU5  (X-ray  1.23A  )  4UU6  (X-ray  1.80A  )  4WSI  (X-ray  2.95A  )  7M4R  (EM  3.65A  )  7NTJ  (X-ray  1.74A  )  7NTK  (X-ray  1.90A  )  7QCS  (X-ray  2.80A  ) 
DBSNP NA 
Subcellular location [CC]Golgi apparatus {ECO:0000269|PubMed:21479189}. Cell membrane;
Peripheral membrane protein. Endomembrane system;
Peripheral membrane protein. Cell junction, tight junction {ECO:0000269|PubMed:20861307}. Cell junction, adherens junction {ECO:0000269|PubMed:16519681}. Cell projection, axon {ECO:0000250|UniProtKB:Q9JLB2}. Perikaryon {ECO:0000250|UniProtKB:Q9JLB2}. Apical cell membrane {ECO:0000269|PubMed:15914641, ECO:0000269|PubMed:16519681, ECO:0000269|PubMed:25385611}. Note=Localized to the tight junctions of epithelial cells (By similarity). Localized to the Golgi apparatus in T lymphocytes (PubMed:21479189). Localized to a subset of intracellular vesicles (By similarity). Localized to the Purkinje cell body and axon (By similarity). Localized to intercellular junctions in vascular endothelial cells (PubMed:27466317). Localized to Schmidt-Lanterman incisures, the adaxonal domain, and the inner part of paranodal loops in myelinating Schwann cells of the sciatic nerve (By similarity). Localized to apical membrane domains of the outer limiting membrane (OLM) junctions in the retina (By similarity). Colocalizes with CRB1 at the OLM, apical to the adherens junction (PubMed:15914641). Colocalizes with MPP1 in the retina at the OLM (PubMed:17584769). Colocalizes with MPP3 to the subapical region of adherens junctions in the retina OLM (PubMed:16519681). {ECO:0000250|UniProtKB:Q9JLB2, ECO:0000269|PubMed:15914641, ECO:0000269|PubMed:16519681, ECO:0000269|PubMed:17584769, ECO:0000269|PubMed:21479189, ECO:0000269|PubMed:27466317}.;
Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:20861307}. Golgi apparatus {ECO:0000269|PubMed:20861307}. Note=(Microbial infection) Following infection by human SARS coronavirus, partially localized at the site of viral replication;
the endoplasmic reticulum-Golgi intermediate compartment, reducing its levels at cell-cell contacts which results in delayed formation of tight junctions and affects establishment of cell polarity. {ECO:0000269|PubMed:20861307}.
Mouse PG classificationNA
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