| Gene Information | |
|---|---|
| Gene Name | PALF |
| Organism | Homo sapiens (Human) |
| Gene Length | 511 |
| Protein Names | Aprataxin and PNK-like factor (EC 3.1.-.-) (Apurinic-apyrimidinic endonuclease APLF) (PNK and APTX-like FHA domain-containing protein) (XRCC1-interacting protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q8IW19 |
| Gene Card | APLF |
| Uniprot ID | Q8IW19 |
| Pfam | PF17913; PF10283 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002419(Rat);0.05(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 2KQB (NMR - ) 2KQC (NMR - ) 2KQD (NMR - ) 2KQE (NMR - ) 2KUO (NMR - ) 5E50 (X-ray 1.38A ) 5W7W (X-ray 1.35A ) 5W7X (X-ray 2.00A ) 5W7Y (X-ray 2.10A ) 6ERF (X-ray 3.01A ) 6TYT (X-ray 2.40A ) 6TYW (X-ray 1.70A ) 6TYZ (X-ray 1.51A ) 6YN1 (X-ray 2.35A ) |
| DBSNP | rs11902811 rs35002937 rs13404469 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:17353262, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:17507382, ECO:0000269|PubMed:23689425}. Chromosome {ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:18474613, ECO:0000269|PubMed:21211721, ECO:0000269|PubMed:21211722, ECO:0000269|PubMed:23689425, ECO:0000269|PubMed:27063109}. Cytoplasm, cytosol {ECO:0000269|PubMed:17353262}. Note=Localizes to DNA damage sites (PubMed:18474613, PubMed:18172500, PubMed:21211721, PubMed:21211722, PubMed:23689425). Accumulates at single-strand breaks and double-strand breaks via the PBZ-type zinc fingers (PubMed:18172500). {ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:18474613, ECO:0000269|PubMed:21211721, ECO:0000269|PubMed:21211722, ECO:0000269|PubMed:23689425}. |
| Mouse PG classification | NA |
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