| Gene Information | |
|---|---|
| Gene Name | APOH |
| Organism | Homo sapiens (Human) |
| Gene Length | 345 |
| Protein Names | Beta-2-glycoprotein 1 (APC inhibitor) (Activated protein C-binding protein) (Anticardiolipin cofactor) (Apolipoprotein H) (Apo-H) (Beta-2-glycoprotein I) (B2GPI) (Beta(2)GPI) |
| Target Name | beta-2-glycoprotein 1 |
| Target Type | Discontinued target |
| Gene Age | 544 ( ENSG00000091583 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P02749 |
| Gene Card | APOH |
| Uniprot ID | P02749 |
| Pfam | PF00084; PF09014 |
| In ASD | no |
| Allosteric Prediction | yes (1.034114506) |
| Ortholog in Animals | Alpaca_ APOH ( ortholog_one2one ) Dog_ APOH ( ortholog_one2one ) GuineaPig_ APOH ( ortholog_one2one ) Macaque_ APOH ( ortholog_one2one ) Mouse_ Apoh ( ortholog_one2one ) Pig_ APOH ( ortholog_one2one ) Rat_ Apoh ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CR1L, SUSD3, F13B, SELP, SEZ6L2, CFHR2, CFHR1, CSMD1, SELE, SRPX, SVEP1, SEZ6, C8A, CD55, CSMD2, PAPPA2, SUSD6, C4BPA, C9, CR1, PAPPA, SELL, CFB, CD46, C4BPB, CR2, C7, CSMD3, CFHR3, CFH, SEZ6L, CFHR4, CFHR5, SRPX2, C8B, PRF1, SUSD4, C6, C2 |
| Tissue | liver, brain |
| Tissue Specificity | Expressed by the liver and secreted in plasma. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1C1Z (X-ray 2.87A ) 1G4F (NMR - ) 1G4G (NMR - ) 1QUB (X-ray 2.70A ) 2KRI (NMR - ) 3OP8 (X-ray 1.90A ) 4JHS (X-ray 3.00A ) 6V06 (X-ray 2.40A ) 6V08 (X-ray 2.58A ) 6V09 (X-ray 2.99A ) 6XSD (X-ray 2.54A ) 6XST (X-ray 2.92A ) 7JIK (X-ray 2.69A ) 7KG4 (X-ray 3.30A ) |
| DBSNP | rs3826358 rs1801692 rs8178847 rs4581 rs1801689 rs1801690 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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