| Gene Information | |
|---|---|
| Gene Name | PAK5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 681 |
| Protein Names | Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6) |
| Target Name | serine/threonine-protein kinase pak 5 |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000101349 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NQU5 |
| Gene Card | PAK6 |
| Uniprot ID | Q9NQU5 |
| Pfam | PF00786; PF00069 |
| In ASD | no |
| Allosteric Prediction | no (-0.919423761) |
| Ortholog in Animals | Alpaca_ PAK5 ( ortholog_one2one ) Dog_ PAK5 ( ortholog_one2one ) Macaque_ PAK5 ( ortholog_one2one ) Mouse_ Pak5 ( ortholog_one2one ) Pig_ PAK5 ( ortholog_one2one ) Rat_ Pak5 ( ortholog_one2one ) Rabbit_ PAK5 ( ortholog_one2one ) |
| Ohnologs | PAK4, PAK6 |
| Paralogs | PAK6, PAK4, SBK2, STK39, MAP4K1, PAK2, PAK1, PAK3, MINK1, TNIK, MAP4K5, SLK, MAP3K14, MAP3K19, STRADB, STK4, MAP3K1, TAOK2, MAP4K3, NRK, STRADA, MAP2K3, STK10, MAP2K6, STK26, TAOK3, TAOK1, MAP3K8, MAP4K2, OXSR1, STK3, NEK4, STK25, STK24, MAP4K4 |
| Tissue | cerebellar.hemisphere, cerebellum |
| Tissue Specificity | Selectively expressed in brain and testis, with lower levels in multiple tissues including prostate and breast. {ECO:0000269|PubMed:11278661, ECO:0000269|PubMed:11773441}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2C30 (X-ray 1.60A ) 2ODB (X-ray 2.40A ) 4KS7 (X-ray 1.40A ) 4KS8 (X-ray 1.95A ) 6QDR (X-ray 1.61A ) 6QDS (X-ray 1.72A ) |
| DBSNP | rs201346085 rs2412504 rs36081263 rs35593179 rs56349744 rs55920845 rs35501648 rs34869667 rs3743135 rs3743137 rs55806501 rs34445577 |
| Subcellular location [CC] | Cytoplasm. Nucleus. Note=Cotranslocates into nucleus with AR in response to androgen induction. |
| Mouse PG classification | NA |
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