| Gene Information | |
|---|---|
| Gene Name | PAK3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 559 |
| Protein Names | Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (Beta-PAK) (Oligophrenin-3) (p21-activated kinase 3) (PAK-3) |
| Target Name | serine/threonine-protein kinase pak 3 |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000077264 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O75914 |
| Gene Card | PAK3 |
| Uniprot ID | O75914 |
| Pfam | PF00786; PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.681678199) |
| Ortholog in Animals | Alpaca_ PAK3 ( ortholog_one2one ) GuineaPig_ PAK3 ( ortholog_one2one ) Macaque_ PAK3 ( ortholog_one2one ) Mouse_ Pak3 ( ortholog_one2one ) Pig_ PAK3 ( ortholog_one2one ) Rat_ Pak3 ( ortholog_one2one ) Rabbit_ PAK3 ( ortholog_one2one ) |
| Ohnologs | PAK1, PAK2 |
| Paralogs | PAK5, PAK6, PAK4, SBK2, STK39, MAP4K1, MINK1, TNIK, MAP4K5, SLK, MAP3K14, MAP3K19, STRADB, STK4, MAP3K1, TAOK2, MAP4K3, NRK, STRADA, MAP2K3, STK10, MAP2K6, STK26, TAOK3, TAOK1, MAP3K8, MAP4K2, OXSR1, STK3, NEK4, STK25, STK24, MAP4K4, PAK1, PAK2 |
| Tissue | brain, pancreas, cerebral.cortex |
| Tissue Specificity | Restricted to the nervous system. Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus. {ECO:0000269|PubMed:12890786}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6FD3 (X-ray 1.52A ) |
| DBSNP | rs121434612 rs121434613 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. |
| Mouse PG classification | NA |
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