Gene Information
Gene NamePAK1
OrganismHomo sapiens (Human)
Gene Length942
Protein NamesSerine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N)
Target Nameserine/threonine-protein kinase pak 1
Target TypeNA
Gene Age1488 ( ENSG00000149269 )
Evolutionary StageEukaryota
AlphaFoldDBQ16512
Gene CardPKN1
Uniprot IDQ16512
PfamPF02185; PF00069; PF00433
In ASDno
Allosteric Predictionyes (1.230258354)
Ortholog in AnimalsAlpaca_ PAK1 ( ortholog_one2one )
Dog_ PAK1 ( ortholog_one2one )
GuineaPig_ PAK1 ( ortholog_one2one )
Macaque_ PAK1 ( ortholog_one2one )
Mouse_ Pak1 ( ortholog_one2one )
Pig_ PAK1 ( ortholog_one2one )
Rat_ Pak1 ( ortholog_one2many )
Rabbit_ PAK1 ( ortholog_one2one )
OhnologsPAK3, PAK2
ParalogsPAK5, PAK6, PAK4, SBK2, STK39, MAP4K1, MINK1, TNIK, MAP4K5, SLK, MAP3K14, MAP3K19, STRADB, STK4, MAP3K1, TAOK2, MAP4K3, NRK, STRADA, MAP2K3, STK10, MAP2K6, STK26, TAOK3, TAOK1, MAP3K8, MAP4K2, OXSR1, STK3, NEK4, STK25, STK24, MAP4K4, PAK3, PAK2
TissueNA
Tissue SpecificityFound ubiquitously. Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas. Expressed in numerous tumor cell lines, especially in breast tumor cells. {ECO:0000269|PubMed:21754995}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1CXZ  (X-ray  2.20A  )  1URF  (NMR  -  )  2RMK  (NMR  -  )  4NKG  (X-ray  2.90A  )  4OTD  (X-ray  2.00A  )  4OTG  (X-ray  2.60A  )  4OTH  (X-ray  1.80A  )  4OTI  (X-ray  1.93A  ) 
DBSNP rs267605306  rs1287763348  rs35132656  rs56273055  rs34309238  rs35416389  rs2230539  rs10846 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:9478917}. Nucleus {ECO:0000269|PubMed:12514133}. Endosome {ECO:0000269|PubMed:9478917}. Cell membrane {ECO:0000250|UniProtKB:Q63433};
Peripheral membrane protein {ECO:0000250|UniProtKB:Q63433}. Cleavage furrow {ECO:0000269|PubMed:17332740}. Midbody {ECO:0000269|PubMed:17332740}. Note=Associates with chromatin in a ligand-dependent manner. Localization to endosomes is mediated via its interaction with RHOB. Association to the cell membrane is dependent on Ser-377 phosphorylation. Accumulates during telophase at the cleavage furrow and finally concentrates around the midbody in cytokinesis. {ECO:0000250|UniProtKB:Q63433, ECO:0000269|PubMed:17332740}.
Mouse PG classificationNA
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