| Gene Information | |
|---|---|
| Gene Name | PAK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 545 |
| Protein Names | Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK) |
| Target Name | serine/threonine-protein kinase pak 1 |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000149269 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q13153 |
| Gene Card | PAK1 |
| Uniprot ID | Q13153 |
| Pfam | PF00786; PF00069 |
| In ASD | yes |
| Allosteric Prediction | yes (1.230258354) |
| Ortholog in Animals | Alpaca_ PAK1 ( ortholog_one2one ) Dog_ PAK1 ( ortholog_one2one ) GuineaPig_ PAK1 ( ortholog_one2one ) Macaque_ PAK1 ( ortholog_one2one ) Mouse_ Pak1 ( ortholog_one2one ) Pig_ PAK1 ( ortholog_one2one ) Rat_ Pak1 ( ortholog_one2many ) Rabbit_ PAK1 ( ortholog_one2one ) |
| Ohnologs | PAK3, PAK2 |
| Paralogs | PAK5, PAK6, PAK4, SBK2, STK39, MAP4K1, MINK1, TNIK, MAP4K5, SLK, MAP3K14, MAP3K19, STRADB, STK4, MAP3K1, TAOK2, MAP4K3, NRK, STRADA, MAP2K3, STK10, MAP2K6, STK26, TAOK3, TAOK1, MAP3K8, MAP4K2, OXSR1, STK3, NEK4, STK25, STK24, MAP4K4, PAK3, PAK2 |
| Tissue | NA |
| Tissue Specificity | Overexpressed in gastric cancer cells and tissues (at protein level) (PubMed:25766321). {ECO:0000269|PubMed:25766321}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1F3M (X-ray 2.30A ) 1YHV (X-ray 1.80A ) 1YHW (X-ray 1.80A ) 1ZSG (NMR - ) 2HY8 (X-ray 2.00A ) 2QME (X-ray 1.75A ) 3DVP (X-ray 2.50A ) 3FXZ (X-ray 1.64A ) 3FY0 (X-ray 2.35A ) 3Q4Z (X-ray 1.89A ) 3Q52 (X-ray 1.80A ) 3Q53 (X-ray 2.09A ) 4DAW (X-ray 2.00A ) 4EQC (X-ray 2.01A ) 4O0R (X-ray 2.40A ) 4O0T (X-ray 2.60A ) 4P90 (X-ray 2.49A ) 4ZJI (X-ray 1.99A ) 4ZJJ (X-ray 2.20A ) 4ZLO (X-ray 2.50A ) 4ZY4 (X-ray 2.60A ) 4ZY5 (X-ray 2.35A ) 4ZY6 (X-ray 2.15A ) 5DEW (X-ray 1.90A ) 5DEY (X-ray 2.10A ) 5DFP (X-ray 2.20A ) 5IME (X-ray 2.22A ) 5KBQ (X-ray 2.58A ) 5KBR (X-ray 2.36A ) 6B16 (X-ray 2.29A ) |
| DBSNP | rs1565638316 rs1565583382 rs35345144 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:25766321}. Cell junction, focal adhesion {ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:25766321}. Cell projection, lamellipodium {ECO:0000269|PubMed:11896197}. Cell membrane {ECO:0000269|PubMed:25766321}. Cell projection, ruffle membrane {ECO:0000269|PubMed:25766321}. Cell projection, invadopodium {ECO:0000269|PubMed:25766321}. Nucleus, nucleoplasm {ECO:0000269|PubMed:23260667}. Chromosome {ECO:0000269|PubMed:23260667}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:27012601}. Note=Colocalizes with RUFY3, F-actin and other core migration components in invadopodia at the cell periphery (PubMed:25766321). Recruited to the cell membrane by interaction with CDC42 and RAC1. Recruited to focal adhesions upon activation. Colocalized with CIB1 within membrane ruffles during cell spreading upon readhesion to fibronectin. Upon DNA damage, translocates to the nucleoplasm when phosphorylated at Thr-212 where is co-recruited with MORC2 on damaged chromatin (PubMed:23260667). Localization to the centrosome does not depend upon the presence of gamma-tubulin (PubMed:27012601). Localization of the active, but not inactive, protein to the adhesions and edge of lamellipodia is mediated by interaction with GIT1 (PubMed:11896197). {ECO:0000250|UniProtKB:P35465, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:25766321, ECO:0000269|PubMed:27012601}. |
| Mouse PG classification | NA |
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