| Gene Information | |
|---|---|
| Gene Name | PAICS |
| Organism | Homo sapiens (Human) |
| Gene Length | 425 |
| Protein Names | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) [Includes: Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC); Phosphoribosylaminoimidazole succinocarboxamide synthetase (EC 6.3.2.6) (SAICAR synthetase)] |
| Target Name | multifunctional protein ade2 |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000128050 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P22234 |
| Gene Card | PAICS |
| Uniprot ID | P22234 |
| Pfam | PF00731; PF01259 |
| In ASD | no |
| Allosteric Prediction | yes (0.341713064) |
| Ortholog in Animals | Alpaca_ PAICS ( ortholog_one2one ) Macaque_ PAICS ( ortholog_one2one ) Mouse_ Paics ( ortholog_one2one ) Pig_ PAICS ( ortholog_one2one ) Rat_ Paics ( ortholog_one2many ) Rat_ AABR07036855.1 ( ortholog_one2many ) Rabbit_ PAICS ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.035294(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2H31 (X-ray 2.80A ) 6YB8 (X-ray 2.36A ) 6YB9 (X-ray 2.41A ) 7ALE (X-ray 2.95A ) |
| DBSNP | rs192831239 rs11549976 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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