Gene Information

Gene Information
Gene Name	PAH
Organism	Homo sapiens (Human)
Gene Length	452
Protein Names	Phenylalanine-4-hydroxylase (PAH) (EC 1.14.16.1) (Phe-4-monooxygenase)
Target Name	phenylalanine hydroxylase
Target Type	Successful target
Gene Age	1064 ( ENSG00000171759 )
Evolutionary Stage	Euk+Bac
AlphaFoldDB	P00439
Gene Card	PAH
Uniprot ID	P00439
Pfam	PF01842; PF00351
In ASD	yes
Allosteric Prediction	yes (1.107873406)
Ortholog in Animals	Alpaca_ PAH ( ortholog_one2one ) Dog_ PAH ( ortholog_one2one ) GuineaPig_ PAH ( ortholog_one2one ) Macaque_ PAH ( ortholog_one2one ) Mouse_ Pah ( ortholog_one2one ) Pig_ PAH ( ortholog_one2one ) Rat_ Pah ( ortholog_one2one ) Rabbit_ PAH ( ortholog_one2one )
Ohnologs	TPH1, TPH2
Paralogs	TH, TPH1, TPH2
Tissue	kidney, liver
Tissue Specificity	NA
Pharmacological Animal Models	NA
Gene Ontology (biological process)
Gene Ontology (cellular component)
Gene Ontology (molecular function)
PDB	1DMW (X-ray 2.00A ) 1J8T (X-ray 1.70A ) 1J8U (X-ray 1.50A ) 1KW0 (X-ray 2.50A ) 1LRM (X-ray 2.10A ) 1MMK (X-ray 2.00A ) 1MMT (X-ray 2.00A ) 1PAH (X-ray 2.00A ) 1TDW (X-ray 2.10A ) 1TG2 (X-ray 2.20A ) 2PAH (X-ray 3.10A ) 3PAH (X-ray 2.00A ) 4ANP (X-ray 2.11A ) 4PAH (X-ray 2.00A ) 5FII (X-ray 1.80A ) 5PAH (X-ray 2.10A ) 6HPO (X-ray 1.67A ) 6HYC (X-ray 3.18A ) 6N1K (X-ray 3.06A ) 6PAH (X-ray 2.15A )
DBSNP	rs62642946 rs199475662 rs62642926 rs62642938 rs62642928 rs62642916 rs62635346 rs1592988883 rs74603784 rs118203925 rs5030841 rs118092776 rs199475598 rs199475567 rs199475651 rs75193786 rs75193786 rs75193786 rs199475643 rs5030842 rs76394784 rs62507347 rs62507347 rs62514902 rs62516151 rs62514903 rs62517167 rs62642929 rs199475571 rs199475606 rs199475572 rs140175796 rs199475599 rs80297647 rs199475597 rs199475587 rs199475663 rs1565853495 rs199475612 rs5030843 rs75166491 rs199475601 rs79635844 rs199475595 rs77554925 rs77554925 rs199475679 rs199475655 rs199475652 rs199475573 rs199475596 rs199475613 rs199475574 rs138809906 rs199475632 rs199475604 rs74486803 rs74486803 rs199475602 rs199475602 rs77958223 rs199475664 rs62514919 rs5030844 rs865899394 rs62517180 rs62517205 rs62514927 rs62508593 rs62517170 rs62508572 rs62508721 rs62514931 rs62517198 rs62516109 rs62508718 rs62514933 rs62514934 rs62507319 rs199475576 rs62517204 rs199475589 rs62508615 rs62516152 rs62508577 rs5030845 rs62517208 rs199475577 rs62517178 rs62508594 rs76687508 rs62508730 rs62508730 rs199475578 rs62508588 rs118203923 rs796052017 rs76212747 rs62508694 rs199475610 rs199475579 rs62507340 rs74503222 rs5030847 rs62644503 rs5030847 rs62642930 rs62642931 rs5030848 rs62642932 rs118203921 rs5030849 rs5030849 rs62642944 rs199475580 rs62517181 rs62508692 rs62514950 rs62514951 rs62517164 rs62514953 rs142934616 rs62508715 rs62514954 rs62516149 rs62516155 rs78655458 rs62516156 rs62507262 rs62508698 rs5030851 rs199475582 rs62517168 rs62508693 rs1486763160 rs62642945 rs62642939 rs62642933 rs5030853 rs199475609 rs199475608 rs199475592 rs62642934 rs62642935 rs62642935 rs62642913 rs62642913 rs62642936 rs62642940 rs199475650 rs62642918 rs62514958 rs62514957 rs62514958 rs62508578 rs62508580 rs62517179 rs62516060 rs62517174 rs62517206 rs62516150 rs62516153 rs62516153 rs62507282 rs62507265 rs62508679 rs62508582 rs62516062 rs62516062 rs62516154 rs62516092 rs62507279 rs62508646 rs62517183 rs62508595 rs62507329 rs62516096 rs62516096 rs62516098 rs62517163 rs62642942 rs62642937 rs62516141 rs62517194 rs62516101 rs62516101 rs5030856 rs62516102 rs62516142 rs62508736 rs62516103 rs5030857 rs62644473 rs62644465 rs5030859 rs5030858 rs62644475 rs79931499 rs62644467 rs5030860 rs62644499 rs62644471 rs62644501 rs199475696 rs199475607 rs76542238
Subcellular location [CC]	NA
Mouse PG classification	HPG
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