Gene Information
Gene NameTRAK1
OrganismHomo sapiens (Human)
Gene Length953
Protein NamesTrafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase-interacting protein) (Protein Milton)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000182606 )
Evolutionary StageEumetazoa
AlphaFoldDBQ9UPV9
Gene CardTRAK1
Uniprot IDQ9UPV9
PfamPF04849; PF12448
In ASDno
Allosteric Predictionno (-0.108903119)
Ortholog in AnimalsAlpaca_ TRAK1 ( ortholog_one2one )
Dog_ TRAK1 ( ortholog_one2one )
GuineaPig_ TRAK1 ( ortholog_one2one )
Macaque_ TRAK1 ( ortholog_one2one )
Mouse_ Trak1 ( ortholog_one2one )
Pig_ TRAK1 ( ortholog_one2one )
Rat_ Trak1 ( ortholog_one2one )
Rabbit_ TRAK1 ( ortholog_one2one )
OhnologsHAP1, TRAK2
ParalogsHAP1, TRAK2
Tissuepineal.gland
Tissue SpecificityHigh expression in spinal cord and moderate expression in all other tissues and specific brain regions examined. Expressed in all cell lines examined. {ECO:0000269|PubMed:18986759}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs770281448 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:18986759}. Nucleus {ECO:0000269|PubMed:12435728}. Mitochondrion {ECO:0000269|PubMed:15644324, ECO:0000269|PubMed:16630562, ECO:0000269|PubMed:18675823, ECO:0000269|PubMed:19528298}. Early endosome {ECO:0000269|PubMed:18675823}. Endosome {ECO:0000269|PubMed:18675823}. Mitochondrion membrane {ECO:0000269|PubMed:24995978}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q6PD31}. Note=Predominantly associated with early endosome. The localization to early endosomes depends on its interaction with HGS/HRS (PubMed:18675823). Colocalizes with MGARP at the mitochondria (PubMed:19528298). {ECO:0000269|PubMed:18675823, ECO:0000269|PubMed:19528298}.
Mouse PG classificationNA
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