| Gene Information | |
|---|---|
| Gene Name | PAFAH |
| Organism | Homo sapiens (Human) |
| Gene Length | 441 |
| Protein Names | Platelet-activating factor acetylhydrolase (PAF acetylhydrolase) (EC 3.1.1.47) (1-alkyl-2-acetylglycerophosphocholine esterase) (2-acetyl-1-alkylglycerophosphocholine esterase) (Group-VIIA phospholipase A2) (gVIIA-PLA2) (LDL-associated phospholipase A2) (LDL-PLA(2)) (PAF 2-acylhydrolase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q13093 |
| Gene Card | PLA2G7 |
| Uniprot ID | Q13093 |
| Pfam | PF03403 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Plasma (PubMed:11590221, PubMed:12821559). Secreted by macrophages (at protein level) (PubMed:11590221). {ECO:0000269|PubMed:11590221, ECO:0000269|PubMed:12821559}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3D59 (X-ray 1.50A ) 3D5E (X-ray 2.10A ) 3F96 (X-ray 2.10A ) 3F97 (X-ray 1.70A ) 3F98 (X-ray 1.70A ) 3F9C (X-ray 2.30A ) 5I8P (X-ray 2.37A ) 5I9I (X-ray 2.70A ) 5JAD (X-ray 2.05A ) 5JAH (X-ray 2.06A ) 5JAL (X-ray 2.06A ) 5JAN (X-ray 2.12A ) 5JAO (X-ray 2.06A ) 5JAP (X-ray 2.46A ) 5JAR (X-ray 2.11A ) 5JAS (X-ray 2.06A ) 5JAT (X-ray 2.04A ) 5JAU (X-ray 1.95A ) 5LP1 (X-ray 1.91A ) 5LYY (X-ray 2.17A ) 5LZ2 (X-ray 2.10A ) 5LZ4 (X-ray 2.07A ) 5LZ5 (X-ray 2.05A ) 5LZ7 (X-ray 2.10A ) 5LZ8 (X-ray 2.11A ) 5LZ9 (X-ray 2.06A ) 5YE7 (X-ray 2.31A ) 5YE8 (X-ray 1.85A ) 5YE9 (X-ray 1.88A ) 5YEA (X-ray 1.80A ) 6M06 (X-ray 2.10A ) 6M07 (X-ray 2.64A ) 6M08 (X-ray 2.19A ) |
| DBSNP | rs45521937 rs1805017 rs45454695 rs1805018 rs76863441 rs201256712 rs1051931 |
| Subcellular location [CC] | Secreted, extracellular space {ECO:0000269|PubMed:10066756, ECO:0000269|PubMed:11590221, ECO:0000269|PubMed:12821559, ECO:0000269|PubMed:18434304}. Note=Associates with both LDL and HDL particles in plasma (PubMed:11590221, PubMed:12821559, PubMed:18434304, PubMed:10066756). Mainly associates with pro-inflammatory electronegative LDL particles (PubMed:12821559). {ECO:0000269|PubMed:10066756, ECO:0000269|PubMed:11590221, ECO:0000269|PubMed:12821559, ECO:0000269|PubMed:18434304}. |
| Mouse PG classification | NA |
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