| Gene Information | |
|---|---|
| Gene Name | PAEP |
| Organism | Homo sapiens (Human) |
| Gene Length | 180 |
| Protein Names | Glycodelin (GD) (Placental protein 14) (PP14) (Pregnancy-associated endometrial alpha-2 globulin) (PAEG) (PEG) (Progestagen-associated endometrial protein) (Progesterone-associated endometrial protein) (Zona-binding inhibitory factor-1) (ZIF-1) |
| Target Name | glycodelin |
| Target Type | NA |
| Gene Age | 244 ( ENSG00000122133 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P09466 |
| Gene Card | PAEP |
| Uniprot ID | P09466 |
| Pfam | PF00061 |
| In ASD | no |
| Allosteric Prediction | no (-0.252974803) |
| Ortholog in Animals | Alpaca_ PAEP ( ortholog_one2one ) Macaque_ PAEP ( ortholog_one2one ) Pig_ PAEP ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LCN9, LCN1, OBP2A, OBP2B, LCN8, LCN10, LCN6, LCN12, PTGDS, LCN2, LCN15, LCNL1 |
| Tissue | endometrium, placenta, uterus, vas.deferens |
| Tissue Specificity | This protein is, the main protein synthesized and secreted in the endometrium from mid-luteal phase of the menstrual cycle and during the first semester of pregnancy (PubMed:3667877). Glycodelin-A is expressed in amniotic fluid, endometrium/decidua and maternal serum (at protein level) (PubMed:3194393). Glycodelin-F is expressed in follicular fluid, luteinized granulosa cells and the oviduct (at protein level) (PubMed:12672671). Glycodelin-S is expressed in seminal plasma and seminal vesicles (at protein level) (PubMed:9239694). Glycodelin-C is detected in cumulus cells (at protein level), but cumulus cells do not synthesize Glycodelin-C but take up and convert glycodelin-A and -F vis glycan remodeling (PubMed:17192260). {ECO:0000269|PubMed:12672671, ECO:0000269|PubMed:17192260, ECO:0000269|PubMed:3194393, ECO:0000269|PubMed:3667877, ECO:0000269|PubMed:9239694}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4R0B (X-ray 2.45A ) |
| DBSNP | rs34284195 rs3748210 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:12672671, ECO:0000269|PubMed:17192260, ECO:0000269|PubMed:3667877}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |