| Gene Information | |
|---|---|
| Gene Name | PADI2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 665 |
| Protein Names | Protein-arginine deiminase type-2 (EC 3.5.3.15) (PAD-H19) (Peptidylarginine deiminase II) (Protein-arginine deiminase type II) |
| Target Name | protein-arginine deiminase type-2 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000117115 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q9Y2J8 |
| Gene Card | PADI2 |
| Uniprot ID | Q9Y2J8 |
| Pfam | PF03068; PF08527; PF08526 |
| In ASD | yes |
| Allosteric Prediction | yes (0.98184118) |
| Ortholog in Animals | Alpaca_ PADI2 ( ortholog_one2one ) Dog_ PADI2 ( ortholog_one2one ) GuineaPig_ PADI2 ( ortholog_one2one ) Macaque_ PADI2 ( ortholog_one2one ) Mouse_ Padi2 ( ortholog_one2one ) Pig_ PADI2 ( ortholog_one2one ) Rat_ Padi2 ( ortholog_one2one ) Rabbit_ PADI2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PADI3, PADI6, PADI4, PADI1 |
| Tissue | NA |
| Tissue Specificity | Detected in keratinocytes in epidermis (at protein level). {ECO:0000269|PubMed:12392711}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4N20 (X-ray 1.66A ) 4N22 (X-ray 1.89A ) 4N24 (X-ray 1.97A ) 4N25 (X-ray 1.93A ) 4N26 (X-ray 1.94A ) 4N28 (X-ray 1.88A ) 4N2A (X-ray 1.70A ) 4N2B (X-ray 1.69A ) 4N2C (X-ray 3.02A ) 4N2D (X-ray 2.00A ) 4N2E (X-ray 1.86A ) 4N2F (X-ray 1.80A ) 4N2G (X-ray 1.85A ) 4N2H (X-ray 1.81A ) 4N2I (X-ray 1.90A ) 4N2K (X-ray 1.57A ) 4N2L (X-ray 2.10A ) 4N2M (X-ray 1.60A ) 4N2N (X-ray 1.80A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:12392711}. |
| Mouse PG classification | NA |
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