Gene Information
Gene NameATG9A
OrganismHomo sapiens (Human)
Gene Length839
Protein NamesAutophagy-related protein 9A (APG9-like 1) (mATG9)
Target NameNA
Target TypeNA
Gene Age1714 ( ENSG00000198925 )
Evolutionary StageEukaryota
AlphaFoldDBQ7Z3C6
Gene CardATG9A
Uniprot IDQ7Z3C6
PfamPF04109
In ASDno
Allosteric Predictionno (-1.113317149)
Ortholog in AnimalsAlpaca_ ATG9A ( ortholog_one2one )
Dog_ ATG9A ( ortholog_one2one )
GuineaPig_ ATG9A ( ortholog_one2one )
Mouse_ Atg9a ( ortholog_one2one )
Pig_ ATG9A ( ortholog_one2one )
Rat_ Atg9a ( ortholog_one2one )
Rabbit_ ATG9A ( ortholog_one2one )
OhnologsATG9B
ParalogsATG9B
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6WQZ  (EM  2.80A  )  6WR4  (EM  2.90A  )  7JLO  (EM  3.40A  )  7JLP  (EM  3.40A  )  7JLQ  (EM  4.00A  ) 
DBSNP rs2276635  rs2276634 
Subcellular location [CC]Preautophagosomal structure membrane {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:32073997, ECO:0000269|PubMed:33106659};
Multi-pass membrane protein {ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:19910472};
Multi-pass membrane protein {ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:16940348, ECO:0000269|PubMed:20124090, ECO:0000269|PubMed:21068542, ECO:0000269|PubMed:27316455, ECO:0000269|PubMed:27663665, ECO:0000269|PubMed:29180427, ECO:0000269|PubMed:33468622, ECO:0000305|PubMed:34432599};
Multi-pass membrane protein {ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659}. Late endosome membrane {ECO:0000269|PubMed:16940348, ECO:0000269|PubMed:20124090, ECO:0000269|PubMed:22456507, ECO:0000269|PubMed:32513819, ECO:0000269|PubMed:33468622};
Multi-pass membrane protein {ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659}. Recycling endosome membrane {ECO:0000269|PubMed:22456507, ECO:0000269|PubMed:29437695};
Multi-pass membrane protein {ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:20124090, ECO:0000269|PubMed:27316455, ECO:0000269|PubMed:27663665};
Multi-pass membrane protein {ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659}. Mitochondrion membrane {ECO:0000305|PubMed:34432599};
Multi-pass membrane protein {ECO:0000255}. Note=Mainly localizes to the trans-Golgi network (TGN) and the endosomal system;
cycles between them though vesicle trafficking (PubMed:27316455, PubMed:27663665). Export from the TGN to promote formation of autophagosomes is mediated by the AP-4 complex (PubMed:29180427, PubMed:30262884). Under amino acid starvation or rapamycin treatment, redistributes to preautophagosomal structure/phagophore assembly site (PAS) (PubMed:16940348). The starvation-induced redistribution depends on ULK1, ATG13, as well as SH3GLB1 (PubMed:16940348). Upon autophagy induction, a small portion transiently localizes to the autophagic membranes (PubMed:22456507). Recruited to damaged mitochondria during mitophagy in a RIMOC1-dependent manner (PubMed:34432599). {ECO:0000269|PubMed:16940348, ECO:0000269|PubMed:22456507, ECO:0000269|PubMed:27316455, ECO:0000269|PubMed:27663665, ECO:0000269|PubMed:29180427, ECO:0000269|PubMed:30262884, ECO:0000269|PubMed:34432599}.
Mouse PG classificationNA
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