| Gene Information | |
|---|---|
| Gene Name | MAGEC2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 373 |
| Protein Names | Melanoma-associated antigen C2 (Cancer/testis antigen 10) (CT10) (Hepatocellular carcinoma-associated antigen 587) (MAGE-C2 antigen) (MAGE-E1 antigen) |
| Target Name | melanoma-associated antigen c2 |
| Target Type | Clinical trial target |
| Gene Age | 1488 ( ENSG00000046774 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q9UBF1 |
| Gene Card | MAGEC2 |
| Uniprot ID | Q9UBF1 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.191807171) |
| Ortholog in Animals | Alpaca_ MAGEC2 ( ortholog_one2one ) Macaque_ MAGEC2 ( ortholog_one2one ) Mouse_ Magea13 ( ortholog_many2many ) Rat_ Magea13 ( ortholog_many2many ) |
| Ohnologs | NA |
| Paralogs | MAGEC1, MAGED4, MAGED4B, MAGEB17, MAGEB1, MAGEA3, MAGEA6, MAGEL2, MAGEA2, MAGEA2B, MAGEA12, NDN, MAGEB6, MAGEB6B, MAGEB2, MAGEH1, MAGEA8, MAGEE2, MAGEA11, MAGEB5, MAGED1, MAGEB10, MAGEA10, MAGEA4, TRO, MAGEB4, MAGEC3, MAGEE1, MAGEA9, MAGEA9B, MAGEB3, NSMCE3, MAGEA1, MAGEB18, MAGEB16, MAGEF1, MAGED2 |
| Tissue | testis |
| Tissue Specificity | Not expressed in normal tissues, except in germ cells in the seminiferous tubules and in Purkinje cells of the cerebellum. Expressed in various tumors, including melanoma, lymphoma, as well as pancreatic cancer, mammary gland cancer, non-small cell lung cancer and liver cancer. In hepatocellular carcinoma, there is an inverse correlation between tumor differentiation and protein expression, i.e. the lower the differentiation, the higher percentage of expression. {ECO:0000269|PubMed:12097419, ECO:0000269|PubMed:12920247}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:12920247}. Nucleus {ECO:0000269|PubMed:12920247}. Note=Nuclear in germ cells. Cytoplasmic in well-differentiated hepatocellular carcinoma, nuclear in moderately- and poorly-differentiated hepatocellular carcinoma. |
| Mouse PG classification | NA |
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