| Gene Information | |
|---|---|
| Gene Name | DSTYK |
| Organism | Homo sapiens (Human) |
| Gene Length | 929 |
| Protein Names | Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000133059 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q6XUX3 |
| Gene Card | DSTYK |
| Uniprot ID | Q6XUX3 |
| Pfam | PF07714 |
| In ASD | no |
| Allosteric Prediction | no (-0.110495991) |
| Ortholog in Animals | Alpaca_ DSTYK ( ortholog_one2one ) Dog_ DSTYK ( ortholog_one2one ) GuineaPig_ DSTYK ( ortholog_one2one ) Macaque_ DSTYK ( ortholog_one2one ) Mouse_ Dstyk ( ortholog_one2one ) Pig_ DSTYK ( ortholog_one2one ) Rat_ Dstyk ( ortholog_one2one ) Rabbit_ DSTYK ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NRBP1, NRBP2, WNK4, WNK1, WNK3, WNK2 |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in skeletal muscle and testis. Expressed in basolateral and apical membranes of all tubular epithelia. Expressed in thin ascending limb of the loop of Henle and the distal convoluted tubule. Expressed in all layers of transitional ureteric epithelium and in the ureteric smooth-muscle cells. Weakly expressed in heart, brain, placenta, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine, white blood cells, stomach, spinal cord and adrenal gland. Is widely distributed in the CNS. Also detected in several tumor cell lines. Expressed in the skin (PubMed:28157540). {ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:17123648, ECO:0000269|PubMed:23862974, ECO:0000269|PubMed:28157540}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs200780796 rs35845538 rs778586547 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17123648, ECO:0000269|PubMed:23862974}. Cell membrane {ECO:0000250|UniProtKB:Q6XUX1}. Apical cell membrane {ECO:0000269|PubMed:23862974}. Basolateral cell membrane {ECO:0000269|PubMed:23862974}. Cell junction {ECO:0000250|UniProtKB:Q6XUX1}. Note=Detected at apical cell-cell junctions. Colocalized with FGF receptors to the cell membrane (By similarity). Detected in basolateral and apical membranes of all tubular epithelia. {ECO:0000250|UniProtKB:Q6XUX1, ECO:0000269|PubMed:23862974}. |
| Mouse PG classification | NA |
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