Gene Information
Gene NamePABPC1
OrganismHomo sapiens (Human)
Gene Length636
Protein NamesPolyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)
Target Namepolyadenylate-binding protein 1
Target TypeClinical trial target
Gene Age544 ( ENSG00000070756 )
Evolutionary StageEukaryota
AlphaFoldDBP11940
Gene CardPABPC1
Uniprot IDP11940
PfamPF00658; PF00076
In ASDyes
Allosteric Predictionyes (0.821561665)
Ortholog in AnimalsAlpaca_ PABPC1 ( ortholog_one2one )
Dog_ PABPC1 ( ortholog_one2one )
Macaque_ PABPC1 ( ortholog_one2one )
Mouse_ Pabpc2 ( ortholog_one2many )
Mouse_ Pabpc6 ( ortholog_one2many )
Pig_ PABPC1 ( ortholog_one2one )
Rat_ Pabpc2 ( ortholog_one2many )
Rat_ Pabpc6 ( ortholog_one2many )
OhnologsPABPC1L, PABPC4
ParalogsPABPC3, RBMS2, RBM24, ELAVL4, ELAVL3, RBMS1, ELAVL2, PUF60, RBM34, RBM45, HNRNPR, SYNCRIP, PABPC1L, PABPC5, RBM14, PABPC1L2A, PABPC1L2B, SF3B4, RBM38, ELAVL1, TARDBP, RBMS3, PABPC4, PABPC4L
TissueNA
Tissue SpecificityUbiquitous.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.05(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1CVJ  (X-ray  2.60A  )  1G9L  (NMR  -  )  1JGN  (NMR  -  )  1JH4  (NMR  -  )  2K8G  (NMR  -  )  2RQG  (NMR  -  )  2RQH  (NMR  -  )  2X04  (X-ray  1.49A  )  3KTP  (X-ray  1.50A  )  3KTR  (X-ray  1.70A  )  3KUI  (X-ray  2.30A  )  3KUJ  (X-ray  1.40A  )  3KUR  (X-ray  2.50A  )  3KUS  (X-ray  1.40A  )  3KUT  (X-ray  1.50A  )  3PKN  (X-ray  1.80A  )  3PTH  (X-ray  1.70A  )  4F02  (X-ray  2.00A  )  4F25  (X-ray  1.90A  )  4F26  (X-ray  2.00A  )  5DX1  (X-ray  1.93A  )  5DX8  (X-ray  1.94A  )  5DXA  (X-ray  2.07A  )  5LGP  (X-ray  2.04A  )  5LGQ  (X-ray  2.11A  )  5LGR  (X-ray  2.00A  )  5LGS  (X-ray  2.10A  )  7BN3  (X-ray  1.93A  ) 
DBSNP NA 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:20573744, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:28733330, ECO:0000269|PubMed:31649314, ECO:0000269|PubMed:7908267, ECO:0000269|PubMed:9582337}. Cytoplasm, Stress granule {ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:27573237}. Nucleus {ECO:0000269|PubMed:18799579, ECO:0000269|PubMed:9582337}. Cell projection, lamellipodium {ECO:0000269|PubMed:28733330}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:17289661). Shuttles between the cytoplasm and the nucleus (PubMed:9582337). During stress and in the absence of DDX3X, localizes to the nucleus (PubMed:21883093). At the leading edge of migrating fibroblasts, colocalizes with DDX3X (PubMed:28733330). Relocalizes to cytoplasmic stress granules upon cellular stress where it colocalizes with ENDOV (PubMed:27573237). In case of HRSV infection, localizes in cytoplasmic inclusion bodies substructures called inclusion bodies associated granules (IBAGs) (PubMed:31649314). {ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:28733330, ECO:0000269|PubMed:31649314, ECO:0000269|PubMed:9582337}.
Mouse PG classificationNA
click here to return to the previous page