| Gene Information | |
|---|---|
| Gene Name | LOXL2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 774 |
| Protein Names | Lysyl oxidase homolog 2 (EC 1.4.3.13) (Lysyl oxidase-like protein 2) (Lysyl oxidase-related protein 2) (Lysyl oxidase-related protein WS9-14) |
| Target Name | lysyl oxidase homolog 2 |
| Target Type | Clinical trial target |
| Gene Age | 987 ( ENSG00000134013 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9Y4K0 |
| Gene Card | LOXL2 |
| Uniprot ID | Q9Y4K0 |
| Pfam | PF01186; PF00530 |
| In ASD | yes |
| Allosteric Prediction | yes (0.031483133) |
| Ortholog in Animals | Alpaca_ LOXL2 ( ortholog_one2one ) Dog_ LOXL2 ( ortholog_one2one ) GuineaPig_ LOXL2 ( ortholog_one2one ) Macaque_ LOXL2 ( ortholog_one2one ) Mouse_ Loxl2 ( ortholog_one2one ) Pig_ LOXL2 ( ortholog_one2one ) Rat_ Loxl2 ( ortholog_one2one ) Rabbit_ LOXL2 ( ortholog_one2one ) |
| Ohnologs | LOXL4, LOXL3 |
| Paralogs | CD6, LOX, SSC4D, SSC5D, LGALS3BP, LOXL4, SCART1, CD163, PRSS12, DMBT1, LOXL3, CD5, LOXL1, CD5L, CD163L1 |
| Tissue | NA |
| Tissue Specificity | Expressed in many tissues (PubMed:10212285). Highest expression in reproductive tissues, placenta, uterus and prostate (PubMed:10212285). In esophageal epithelium, expressed in the basal, prickle and granular cell layers (PubMed:22204712). Up-regulated in a number of cancers cells and tissues. {ECO:0000269|PubMed:10212285, ECO:0000269|PubMed:22204712}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5ZE3 (X-ray 2.40A ) |
| DBSNP | rs4602894 rs1063582 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269|PubMed:23319596}. Nucleus {ECO:0000269|PubMed:22204712, ECO:0000269|PubMed:24414204}. Chromosome {ECO:0000269|PubMed:27735137}. Endoplasmic reticulum {ECO:0000269|PubMed:28332555}. Note=Associated with chromatin (PubMed:27735137). It is unclear how LOXL2 is nuclear as it contains a signal sequence and has been shown to be secreted (PubMed:23319596). However, a number of reports confirm its intracellular location and its key role in transcription regulation (PubMed:22204712, PubMed:22483618). {ECO:0000269|PubMed:22204712, ECO:0000269|PubMed:23319596, ECO:0000269|PubMed:24414204, ECO:0000269|PubMed:27735137}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |