| Gene Information | |
|---|---|
| Gene Name | PAB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 636 |
| Protein Names | Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P11940 |
| Gene Card | PABPC1 |
| Uniprot ID | P11940 |
| Pfam | PF00658; PF00076 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.05(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1CVJ (X-ray 2.60A ) 1G9L (NMR - ) 1JGN (NMR - ) 1JH4 (NMR - ) 2K8G (NMR - ) 2RQG (NMR - ) 2RQH (NMR - ) 2X04 (X-ray 1.49A ) 3KTP (X-ray 1.50A ) 3KTR (X-ray 1.70A ) 3KUI (X-ray 2.30A ) 3KUJ (X-ray 1.40A ) 3KUR (X-ray 2.50A ) 3KUS (X-ray 1.40A ) 3KUT (X-ray 1.50A ) 3PKN (X-ray 1.80A ) 3PTH (X-ray 1.70A ) 4F02 (X-ray 2.00A ) 4F25 (X-ray 1.90A ) 4F26 (X-ray 2.00A ) 5DX1 (X-ray 1.93A ) 5DX8 (X-ray 1.94A ) 5DXA (X-ray 2.07A ) 5LGP (X-ray 2.04A ) 5LGQ (X-ray 2.11A ) 5LGR (X-ray 2.00A ) 5LGS (X-ray 2.10A ) 7BN3 (X-ray 1.93A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:20573744, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:28733330, ECO:0000269|PubMed:31649314, ECO:0000269|PubMed:7908267, ECO:0000269|PubMed:9582337}. Cytoplasm, Stress granule {ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:27573237}. Nucleus {ECO:0000269|PubMed:18799579, ECO:0000269|PubMed:9582337}. Cell projection, lamellipodium {ECO:0000269|PubMed:28733330}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:17289661). Shuttles between the cytoplasm and the nucleus (PubMed:9582337). During stress and in the absence of DDX3X, localizes to the nucleus (PubMed:21883093). At the leading edge of migrating fibroblasts, colocalizes with DDX3X (PubMed:28733330). Relocalizes to cytoplasmic stress granules upon cellular stress where it colocalizes with ENDOV (PubMed:27573237). In case of HRSV infection, localizes in cytoplasmic inclusion bodies substructures called inclusion bodies associated granules (IBAGs) (PubMed:31649314). {ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:28733330, ECO:0000269|PubMed:31649314, ECO:0000269|PubMed:9582337}. |
| Mouse PG classification | NA |
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