Gene Information
Gene NameSHTN1
OrganismHomo sapiens (Human)
Gene Length631
Protein NamesShootin-1 (Shootin1)
Target NameNA
Target TypeNA
Gene Age1488 ( ENSG00000187164 )
Evolutionary StageEumetazoa
AlphaFoldDBA0MZ66
Gene CardSHTN1
Uniprot IDA0MZ66
PfamNA
In ASDno
Allosteric Predictionno (-0.998754182)
Ortholog in AnimalsAlpaca_ SHTN1 ( ortholog_one2one )
Dog_ SHTN1 ( ortholog_one2one )
GuineaPig_ SHTN1 ( ortholog_one2one )
Macaque_ SHTN1 ( ortholog_one2one )
Mouse_ Shtn1 ( ortholog_one2one )
Pig_ SHTN1 ( ortholog_one2one )
Rat_ Shtn1 ( ortholog_one2one )
Rabbit_ SHTN1 ( ortholog_one2one )
OhnologsNA
ParalogsFHOD3, FHOD1, FHDC1, GRID2IP, FAM47B, DAAM2, FNBP4, FAM47C, FAM47A, FMNL1, DAAM1, DIAPH3, DIAPH2, FMN2, FMNL3, FMNL2, INF2, DIAPH1
TissueNA
Tissue SpecificityNA
Pharmacological Animal Models0.000730(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP NA 
Subcellular location [CC]Perikaryon {ECO:0000250|UniProtKB:Q8K2Q9}. Cell projection, axon {ECO:0000250|UniProtKB:Q8K2Q9}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q8K2Q9}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8K2Q9}. Cell projection, filopodium {ECO:0000250|UniProtKB:A0MZ67}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:A0MZ67}. Note=Localizes in multiple growth cones at neurite tips before the neuronal symmetry-breaking step. Accumulates in growth cones of a single nascent axon in a neurite length-dependent manner during the neuronal symmetry-breaking step;
when absent from the nascent axon's siblings, probably due to competitive transport, prevents the formation of surplus axons. Transported anterogradely from the soma to the axon growth cone in an actin and myosin-dependent manner and passively diffuses back to the cell bodies. Colocalized with L1CAM in close apposition with actin filaments in filopodia and lamellipodia of axonal growth cones in hippocampal neurons. Exhibits retrograde movements in filopodia and lamellopodia of axonal growth cones. Colocalized with KIF20B along microtubules to the tip of the growing cone in primary hippocampal neurons. Recruited to the growth cone of developing axon in a KIF20B- and microtubule-dependent manner. {ECO:0000250|UniProtKB:A0MZ67, ECO:0000250|UniProtKB:Q8K2Q9}.
Mouse PG classificationNA
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