| Gene Information | |
|---|---|
| Gene Name | P73 |
| Organism | Homo sapiens (Human) |
| Gene Length | 636 |
| Protein Names | Tumor protein p73 (p53-like transcription factor) (p53-related protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | O15350 |
| Gene Card | TP73 |
| Uniprot ID | O15350 |
| Pfam | PF00870; PF07710; PF07647 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in striatal neurons of patients with Huntington disease (at protein level). Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas. Highly expressed in fetal tissue. Expressed in the respiratory epithelium (PubMed:34077761). {ECO:0000269|PubMed:11753569, ECO:0000269|PubMed:16461361, ECO:0000269|PubMed:34077761}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001596(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1COK (NMR - ) 1DXS (X-ray 2.54A ) 2KBY (NMR - ) 2MPS (NMR - ) 2NB1 (NMR - ) 2WQI (X-ray 1.70A ) 2WQJ (X-ray 2.00A ) 2WTT (X-ray 2.30A ) 2XWC (X-ray 1.82A ) 3VD0 (X-ray 2.95A ) 3VD1 (X-ray 2.95A ) 3VD2 (X-ray 4.00A ) 4A63 (X-ray 2.27A ) 4G82 (X-ray 3.10A ) 4G83 (X-ray 4.00A ) 4GUO (X-ray 3.19A ) 4GUQ (X-ray 3.70A ) 5HOB (X-ray 1.22A ) 5HOC (X-ray 1.36A ) 5KBD (X-ray 2.80A ) 6FGS (NMR - ) 6IJQ (NMR - ) 7EZJ (X-ray 2.90A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:24314664}. Cytoplasm. Note=Accumulates in the nucleus in response to DNA damage. |
| Mouse PG classification | NA |
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