| Gene Information | |
|---|---|
| Gene Name | GLRA2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 452 |
| Protein Names | Glycine receptor subunit alpha-2 |
| Target Name | glycine receptors |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000101958 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P23416 |
| Gene Card | GLRA2 |
| Uniprot ID | P23416 |
| Pfam | PF02931; PF02932 |
| In ASD | no |
| Allosteric Prediction | yes (0.950547163) |
| Ortholog in Animals | Alpaca_ GLRA2 ( ortholog_one2one ) Dog_ GLRA2 ( ortholog_one2one ) GuineaPig_ GLRA2 ( ortholog_one2one ) Macaque_ GLRA2 ( ortholog_one2one ) Mouse_ Glra2 ( ortholog_one2one ) Pig_ GLRA2 ( ortholog_one2one ) Rat_ Glra2 ( ortholog_one2one ) Rabbit_ GLRA2 ( ortholog_one2one ) |
| Ohnologs | GLRA4, GABRP, GLRB, GABRR2, GLRA3, GABRA6, GLRA1 |
| Paralogs | CHRNB1, GABRR2, CHRNA6, CHRNB4, CHRNA4, GABRQ, HTR3E, CHRNA1, CHRNA3, GABRA5, HTR3B, GLRA1, GABRG3, GABRA2, GABRB3, GABRP, HTR3C, HTR3D, GABRG1, CHRNA7, CHRFAM7A, GABRD, GABRR1, CHRNA5, GABRA6, GABRA4, GLRA3, GABRE, CHRNE, GABRG2, CHRND, CHRNA2, CHRNA10, CHRNA9, GABRA3, HTR3A, ZACN, CHRNB3, CHRNB2, CHRNG, GABRR3, GABRB2, GABRB1, GABRA1, GLRB |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5BKF (EM 3.60A ) 5BKG (EM 3.80A ) 7KUY (EM 3.60A ) 7L31 (EM 3.80A ) |
| DBSNP | NA |
| Subcellular location [CC] | Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q7TNC8}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23415}. Synapse {ECO:0000250|UniProtKB:Q7TNC8}. Cell membrane {ECO:0000269|PubMed:15302677, ECO:0000269|PubMed:16144831, ECO:0000269|PubMed:2155780, ECO:0000269|PubMed:23895467, ECO:0000269|PubMed:25445488, ECO:0000269|PubMed:26370147}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23415}. Cell projection {ECO:0000250|UniProtKB:Q7TNC8}. |
| Mouse PG classification | NA |
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