| Gene Information | |
|---|---|
| Gene Name | ATRX |
| Organism | Homo sapiens (Human) |
| Gene Length | 2492 |
| Protein Names | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000085224 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P46100 |
| Gene Card | ATRX |
| Uniprot ID | P46100 |
| Pfam | PF17981; PF00271; PF00176 |
| In ASD | no |
| Allosteric Prediction | yes (0.279393587) |
| Ortholog in Animals | Alpaca_ ATRX ( ortholog_one2one ) Dog_ ATRX ( ortholog_one2one ) GuineaPig_ ATRX ( ortholog_one2one ) Macaque_ ATRX ( ortholog_one2one ) Mouse_ Atrx ( ortholog_one2one ) Pig_ ATRX ( ortholog_one2one ) Rat_ Atrx ( ortholog_one2one ) Rabbit_ ATRX ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SMARCA1, RAD54B, HLTF, HELLS, SHPRH, BTAF1, ZRANB3, SMARCA5, TTF2, SMARCA2, CHD9, SMARCAL1, CHD1L, CHD3, RAD54L2, SMARCAD1, CHD4, INO80, CHD6, SRCAP, CHD1, CHD2, RAD54L, CHD7, CHD8, EP400, ERCC6, ERCC6L, CHD5, SMARCA4 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.008097(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 2JM1 (NMR - ) 2LBM (NMR - ) 2LD1 (NMR - ) 3QL9 (X-ray 0.93A ) 3QLA (X-ray 1.60A ) 3QLC (X-ray 2.50A ) 3QLN (X-ray 1.90A ) 4W5A (X-ray 2.60A ) 5GRQ (X-ray 1.58A ) 5Y18 (X-ray 2.20A ) 5Y6O (X-ray 3.10A ) 6G0O (X-ray 1.40A ) |
| DBSNP | rs398123425 rs122445103 rs1057518708 rs122445111 rs122445105 rs1603226766 rs122445109 rs35738915 rs1051678 rs1051680 rs3088074 rs1602995714 rs122445093 rs122445094 rs122445106 rs122445095 rs122445104 rs45439799 rs122445096 rs122445110 rs122445097 rs122445101 rs122445098 rs122445112 |
| Subcellular location [CC] | Nucleus. Chromosome, telomere. Nucleus, PML body. Note=Associated with pericentromeric heterochromatin during interphase and mitosis, probably by interacting with CBX5/HP1 alpha. Colocalizes with histone H3.3, DAXX, HIRA and ASF1A at PML-nuclear bodies. Colocalizes with cohesin (SMC1 and SMC3) and MECP2 at the maternal H19 ICR (By similarity). {ECO:0000250}. |
| Mouse PG classification | LPG |
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