Gene Information
Gene NamePLEKHA6
OrganismHomo sapiens (Human)
Gene Length1048
Protein NamesPleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3)
Target NameNA
Target TypeNA
Gene Age544 ( ENSG00000143850 )
Evolutionary StageVertebrata
AlphaFoldDBQ9Y2H5
Gene CardPLEKHA6
Uniprot IDQ9Y2H5
PfamPF00169
In ASDno
Allosteric Predictionno (-1.090824526)
Ortholog in AnimalsAlpaca_ PLEKHA6 ( ortholog_one2one )
Dog_ PLEKHA6 ( ortholog_one2one )
GuineaPig_ PLEKHA6 ( ortholog_one2one )
Macaque_ PLEKHA6 ( ortholog_one2one )
Mouse_ Plekha6 ( ortholog_one2one )
Pig_ PLEKHA6 ( ortholog_one2one )
Rat_ Plekha6 ( ortholog_one2one )
Rabbit_ PLEKHA6 ( ortholog_one2one )
OhnologsPLEKHA5, PLEKHA7
ParalogsPLEKHA5, PLEKHA7, PLEKHA4
TissueNA
Tissue SpecificityHighly expressed in heart, kidney and throughout the brain.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2D9Y  (NMR  2YRY  (NMR 
DBSNP rs10900571  rs10900562 
Subcellular location [CC]NA
Mouse PG classificationNA
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