| Gene Information | |
|---|---|
| Gene Name | DCTN3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 186 |
| Protein Names | Dynactin subunit 3 (Dynactin complex subunit 22 kDa subunit) (p22) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000137100 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O75935 |
| Gene Card | DCTN3 |
| Uniprot ID | O75935 |
| Pfam | PF07426 |
| In ASD | no |
| Allosteric Prediction | no (-0.25464574) |
| Ortholog in Animals | Alpaca_ DCTN3 ( ortholog_one2one ) Dog_ DCTN3 ( ortholog_one2one ) GuineaPig_ DCTN3 ( ortholog_one2one ) Macaque_ DCTN3 ( ortholog_one2one ) Mouse_ Dctn3 ( ortholog_one2one ) Pig_ DCTN3 ( ortholog_one2one ) Rat_ AABR07000222.1 ( ortholog_one2one ) Rabbit_ DCTN3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. Highly expressed in muscle and pancreas and detected at lower levels in brain. {ECO:0000269|PubMed:9722614}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:9722614}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:9722614}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:9722614}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:9722614}. Cleavage furrow {ECO:0000269|PubMed:9722614}. Midbody {ECO:0000269|PubMed:9722614}. Note=Localizes to punctate cytoplasmic structures and to the centrosome during interphase, and to kinetochores and to spindle poles throughout mitosis. Colocalizes with dynein to the cleavage furrow and to midbody of dividing cells. |
| Mouse PG classification | NA |
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