| Gene Information | |
|---|---|
| Gene Name | OTX2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 289 |
| Protein Names | Homeobox protein OTX2 (Orthodenticle homolog 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000165588 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P32243 |
| Gene Card | OTX2 |
| Uniprot ID | P32243 |
| Pfam | PF00046; PF03529 |
| In ASD | no |
| Allosteric Prediction | no (-1.079020399) |
| Ortholog in Animals | Alpaca_ OTX2 ( ortholog_one2one ) Dog_ OTX2 ( ortholog_one2one ) GuineaPig_ OTX2 ( ortholog_one2one ) Macaque_ OTX2 ( ortholog_one2one ) Mouse_ Otx2 ( ortholog_one2one ) Pig_ OTX2 ( ortholog_one2one ) Rat_ Otx2 ( ortholog_one2one ) Rabbit_ OTX2 ( ortholog_one2one ) |
| Ohnologs | CRX, OTX1 |
| Paralogs | ARGFX, PAX7, PAX3, ALX4, PAX2, UNCX, RAX2, PAX8, DMBX1, DPRX, PAX5, ISX, ALX3, RHOXF2B, RHOXF2, GSC2, SEBOX, RAX, DRGX, ARX, RHOXF1, PITX3, PRRX1, SHOX, SHOX2, PRRX2, PAX4, EVX1, PAX1, PITX2, PHOX2A, CRX, PHOX2B, EVX2, ALX1, VSX2, MIXL1, DUXA, PAX6, OTP, HESX1, NOBOX, PROP1, PAX9, GSC, ESX1, DUXB, DUX4, PITX1, OTX1 |
| Tissue | pineal.gland |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs786205224 rs104894464 rs376333965 rs753783256 rs199761861 rs370761964 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:19414065}. |
| Mouse PG classification | HPG |
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