| Gene Information | |
|---|---|
| Gene Name | ADRB2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 413 |
| Protein Names | Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor) |
| Target Name | adrenergic receptor beta-2 |
| Target Type | Successful target |
| Gene Age | 680 ( ENSG00000169252 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P07550 |
| Gene Card | ADRB2 |
| Uniprot ID | P07550 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (2.366634703) |
| Ortholog in Animals | Alpaca_ ADRB2 ( ortholog_one2one ) Dog_ ADRB2 ( ortholog_one2one ) GuineaPig_ ADRB2 ( ortholog_one2one ) Macaque_ ADRB2 ( ortholog_one2one ) Mouse_ Adrb2 ( ortholog_one2one ) Pig_ ADRB2 ( ortholog_one2one ) Rat_ Adrb2 ( ortholog_one2one ) Rabbit_ ADRB2 ( ortholog_one2one ) |
| Ohnologs | ADRB1, ADRA1D, ADRB3 |
| Paralogs | OR56A4, ADRA2A, ADRA2B, OR56A1, OR56A3, OR56A5, DRD2, ADRA1B, ADRB3, ADRA1D, OR5T2, OR5T3, OR5T1, ADRA1A, GPR101, ADRB1, OR13F1, ADRA2C |
| Tissue | adipose.tissue, lung, spleen |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002865(Rat);0.011765(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1GQ4 (X-ray 1.90A ) 2R4R (X-ray 3.40A ) 2R4S (X-ray 3.40A ) 2RH1 (X-ray 2.40A ) 3D4S (X-ray 2.80A ) 3KJ6 (X-ray 3.40A ) 3NY8 (X-ray 2.84A ) 3NY9 (X-ray 2.84A ) 3NYA (X-ray 3.16A ) 3P0G (X-ray 3.50A ) 3PDS (X-ray 3.50A ) 3SN6 (X-ray 3.20A ) 4GBR (X-ray 3.99A ) 4LDE (X-ray 2.79A ) 4LDL (X-ray 3.10A ) 4LDO (X-ray 3.20A ) 4QKX (X-ray 3.30A ) 5D5A (X-ray 2.48A ) 5D5B (X-ray 3.80A ) 5D6L (X-ray 3.20A ) 5JQH (X-ray 3.20A ) 5X7D (X-ray 2.70A ) 6E67 (X-ray 3.70A ) 6KR8 (NMR - ) 6MXT (X-ray 2.96A ) 6N48 (X-ray 3.20A ) 6NI3 (EM 3.80A ) 6OBA (X-ray 3.10A ) 6PRZ (X-ray 2.80A ) 6PS0 (X-ray 3.40A ) 6PS1 (X-ray 3.20A ) 6PS2 (X-ray 2.40A ) 6PS3 (X-ray 2.50A ) 6PS4 (X-ray 2.60A ) 6PS5 (X-ray 2.90A ) 6PS6 (X-ray 2.70A ) 7BZ2 (EM 3.82A ) 7DHI (EM 3.26A ) 7DHR (EM 3.80A ) |
| DBSNP | rs33973603 rs1042713 rs1042714 rs990810566 rs1800888 rs3729943 rs771585355 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:19584355, ECO:0000269|PubMed:20559325, ECO:0000269|PubMed:23166351, ECO:0000269|PubMed:25220262, ECO:0000269|PubMed:2831218, ECO:0000269|PubMed:7915137}; Multi-pass membrane protein {ECO:0000269|PubMed:19584355}. Early endosome {ECO:0000269|PubMed:20559325}. Golgi apparatus {ECO:0000269|PubMed:27481942}. Note=Colocalizes with VHL at the cell membrane (PubMed:19584355). Activated receptors are internalized into endosomes prior to their degradation in lysosomes (PubMed:20559325). Activated receptors are also detected within the Golgi apparatus (PubMed:27481942). {ECO:0000269|PubMed:19584355, ECO:0000269|PubMed:20559325, ECO:0000269|PubMed:27481942}. |
| Mouse PG classification | LPG |
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