| Gene Information | |
|---|---|
| Gene Name | CIRBP |
| Organism | Homo sapiens (Human) |
| Gene Length | 172 |
| Protein Names | Cold-inducible RNA-binding protein (A18 hnRNP) (Glycine-rich RNA-binding protein CIRP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000099622 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q14011 |
| Gene Card | CIRBP |
| Uniprot ID | Q14011 |
| Pfam | PF00076 |
| In ASD | no |
| Allosteric Prediction | no (-0.832273721) |
| Ortholog in Animals | Alpaca_ CIRBP ( ortholog_one2one ) Dog_ CIRBP ( ortholog_one2one ) GuineaPig_ CIRBP ( ortholog_one2one ) Mouse_ Cirbp ( ortholog_one2one ) Pig_ CIRBP ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RBM46, RBM19, MSI2, HNRNPA1L2, HNRNPA1L3, HNRNPA1, A1CF, RBM39, RBM23, TIAL1, DAZAP1, RBMX, RBMXL1, HNRNPA0, HNRNPAB, HNRNPA3, RBMY1D, RBMY1B, RBMY1A1, RBMY1J, RBMY1F, RBMY1E, MSI1, RBM47, TRNAU1AP, HNRNPA2B1, RBMXL2, RBMXL3, RBM4, RBM4B, HNRNPD, DND1, NCL, HNRNPDL, TIA1, RBM3 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1X5S (NMR - ) 5TBX (X-ray 1.77A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus, nucleoplasm {ECO:0000269|PubMed:11574538}. Cytoplasm {ECO:0000269|PubMed:11574538}. Note=Translocates from the nucleus to the cytoplasm after exposure to UV radiation. Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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