| Gene Information | |
|---|---|
| Gene Name | TMPRSS12 |
| Organism | Homo sapiens (Human) |
| Gene Length | 348 |
| Protein Names | Transmembrane protease serine 12 (EC 3.4.21.-) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 244 ( ENSG00000186452 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q86WS5 |
| Gene Card | TMPRSS12 |
| Uniprot ID | Q86WS5 |
| Pfam | PF00089 |
| In ASD | no |
| Allosteric Prediction | no (-0.71732595) |
| Ortholog in Animals | Alpaca_ TMPRSS12 ( ortholog_one2one ) Dog_ TMPRSS12 ( ortholog_one2one ) GuineaPig_ TMPRSS12 ( ortholog_one2one ) Macaque_ TMPRSS12 ( ortholog_one2one ) Mouse_ Tmprss12 ( ortholog_one2one ) Pig_ TMPRSS12 ( ortholog_one2one ) Rat_ Tmprss12 ( ortholog_one2one ) Rabbit_ TMPRSS12 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | OVCH1, PLAT, PRSS48, PLGLB1, PLGLB2, PLG, GZMM, KLK15, PRSS37, PRSS27, PRSS33, PRSS57, PRSS50, KLK9 |
| Tissue | testis |
| Tissue Specificity | In testis, expressed in spermatocytes and spermatids. Expressed in colorectal cancer (at protein level). {ECO:0000269|PubMed:23436708}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs10876100 rs829121 rs861204 |
| Subcellular location [CC] | Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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