| Gene Information | |
|---|---|
| Gene Name | OSBPL8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 889 |
| Protein Names | Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000091039 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9BZF1 |
| Gene Card | OSBPL8 |
| Uniprot ID | Q9BZF1 |
| Pfam | PF01237; PF00169 |
| In ASD | no |
| Allosteric Prediction | no (-0.319483944) |
| Ortholog in Animals | Alpaca_ OSBPL8 ( ortholog_one2one ) Dog_ OSBPL8 ( ortholog_one2one ) GuineaPig_ OSBPL8 ( ortholog_one2one ) Macaque_ OSBPL8 ( ortholog_one2one ) Mouse_ Osbpl8 ( ortholog_one2one ) Pig_ OSBPL8 ( ortholog_one2one ) Rat_ Osbpl8 ( ortholog_one2one ) Rabbit_ OSBPL8 ( ortholog_one2one ) |
| Ohnologs | OSBPL5 |
| Paralogs | OSBPL10, OSBPL2, OSBP2, OSBPL1A, OSBP, OSBPL3, OSBPL5, OSBPL9, OSBPL11, OSBPL6, OSBPL7 |
| Tissue | NA |
| Tissue Specificity | Widely expressed (PubMed:11735225). Expressed at higher level in macrophages (PubMed:17991739). {ECO:0000269|PubMed:11735225, ECO:0000269|PubMed:17991739}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1V88 (NMR - ) 5U77 (X-ray 2.16A ) 5U78 (X-ray 1.98A ) |
| DBSNP | NA |
| Subcellular location [CC] | [Isoform 1]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17991739, ECO:0000269|PubMed:26206935}; Single-pass membrane protein {ECO:0000269|PubMed:17991739}. Nucleus membrane {ECO:0000269|PubMed:21698267}. Note=The presence of the N-terminus extension contains an overall negative charge that may explain the weak localization to the cortical endoplasmic reticulum (Probable). {ECO:0000305|PubMed:26206935}.; [Isoform 3]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:26206935}; Single-pass membrane protein. Note=Localizes to the cortical endoplasmic reticulum at the endoplasmic reticulum-plasma membrane contact sites. {ECO:0000269|PubMed:26206935}. |
| Mouse PG classification | NA |
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