| Gene Information | |
|---|---|
| Gene Name | OSBPL6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 934 |
| Protein Names | Oxysterol-binding protein-related protein 6 (ORP-6) (OSBP-related protein 6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000079156 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9BZF3 |
| Gene Card | OSBPL6 |
| Uniprot ID | Q9BZF3 |
| Pfam | PF01237; PF15409 |
| In ASD | no |
| Allosteric Prediction | no (-0.28709719) |
| Ortholog in Animals | Alpaca_ OSBPL6 ( ortholog_one2one ) Dog_ OSBPL6 ( ortholog_one2one ) GuineaPig_ OSBPL6 ( ortholog_one2one ) Macaque_ OSBPL6 ( ortholog_one2one ) Mouse_ Osbpl6 ( ortholog_one2one ) Pig_ OSBPL6 ( ortholog_one2one ) Rat_ Osbpl6 ( ortholog_one2one ) Rabbit_ OSBPL6 ( ortholog_one2one ) |
| Ohnologs | OSBPL7, OSBPL3 |
| Paralogs | OSBPL10, OSBPL2, OSBP2, OSBPL1A, OSBP, OSBPL8, OSBPL3, OSBPL5, OSBPL9, OSBPL11, OSBPL7 |
| Tissue | NA |
| Tissue Specificity | Expressed in brain and striated muscle (at protein level) (PubMed:14593528). Widely expressed (PubMed:11735225). Expressed in skeletal muscle (PubMed:14593528). |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs35032920 rs34874235 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:14593528, ECO:0000269|PubMed:30028970}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:14593528, ECO:0000269|PubMed:26941018, ECO:0000269|PubMed:30028970}; Peripheral membrane protein {ECO:0000305}. Nucleus envelope {ECO:0000269|PubMed:14593528}. Cell membrane {ECO:0000269|PubMed:14593528, ECO:0000269|PubMed:30028970}; Peripheral membrane protein {ECO:0000305}. Endosome membrane {ECO:0000269|PubMed:26941018}; Peripheral membrane protein {ECO:0000305}. Note=Co-localizes with OSBPL3 at contact sites between the plasma membrane and the endoplasmic reticulum. {ECO:0000250|UniProtKB:Q8BXR9}. |
| Mouse PG classification | NA |
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