| Gene Information | |
|---|---|
| Gene Name | OSBPL2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 480 |
| Protein Names | Oxysterol-binding protein-related protein 2 (ORP-2) (OSBP-related protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000130703 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9H1P3 |
| Gene Card | OSBPL2 |
| Uniprot ID | Q9H1P3 |
| Pfam | PF01237 |
| In ASD | no |
| Allosteric Prediction | no (-0.748408123) |
| Ortholog in Animals | Alpaca_ OSBPL2 ( ortholog_one2one ) Dog_ OSBPL2 ( ortholog_one2one ) GuineaPig_ OSBPL2 ( ortholog_one2one ) Macaque_ OSBPL2 ( ortholog_one2one ) Mouse_ Osbpl2 ( ortholog_one2one ) Pig_ OSBPL2 ( ortholog_one2one ) Rat_ Osbpl2 ( ortholog_one2one ) Rabbit_ OSBPL2 ( ortholog_one2one ) |
| Ohnologs | OSBPL1A |
| Paralogs | OSBPL10, OSBP2, OSBPL1A, OSBP, OSBPL8, OSBPL3, OSBPL5, OSBPL9, OSBPL11, OSBPL6, OSBPL7 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 5ZM8 (X-ray 2.70A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:19224871, ECO:0000269|PubMed:30581148}. Lipid droplet {ECO:0000269|PubMed:19224871}. Cell membrane {ECO:0000269|PubMed:30581148}; Peripheral membrane protein {ECO:0000269|PubMed:30581148}; Cytoplasmic side {ECO:0000269|PubMed:30581148}. Note=Detected on the surface of cytosolic lipid droplets (PubMed:19224871). Recruited to the cell membrane by phosphatidylinositol-phosphate binding (PubMed:30581148). {ECO:0000269|PubMed:19224871, ECO:0000269|PubMed:30581148}. |
| Mouse PG classification | NA |
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