| Gene Information | |
|---|---|
| Gene Name | ORP3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 887 |
| Protein Names | Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9H4L5 |
| Gene Card | OSBPL3 |
| Uniprot ID | Q9H4L5 |
| Pfam | PF01237; PF15409 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in a subset of small lymphocytes (at protein level). Expressed at high concentration in kidney, lymph node and thymus. Expressed at moderate concentration in stomach, jejunum, ileum, appendix, spleen, leukocytes, trachea, lung and thyroid gland. Expressed at low concentration in whole brain, esophagus, duodenum, ileocecum, colon, skeletal muscle, bone marrow, placenta and mammary gland (PubMed:14593528). Isoform 1a, isoform 1b, isoform 1c and isoform 1d are highly expressed in brain, bone marrow, colon, kidney, lung, skeletal muscle, spleen, thymus and thyroid. Not expressed in heart and liver. Isoform 2a, isoform 2b, isoform 2c and isoform 2d are expressed in brain, bone marrow, kidney, skeletal muscle, spleen, thymus and thyroid. Not expressed in heart, liver and lung (PubMed:12590732). {ECO:0000269|PubMed:12590732, ECO:0000269|PubMed:14593528}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 7CYZ (X-ray 2.10A ) 7DEI (X-ray 2.60A ) 7DEJ (X-ray 2.70A ) |
| DBSNP | rs11768296 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:16143324}; Peripheral membrane protein {ECO:0000269|PubMed:16143324}. Cytoplasm, cytosol {ECO:0000269|PubMed:16143324}. Cell membrane {ECO:0000269|PubMed:14593528, ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}; Peripheral membrane protein {ECO:0000269|PubMed:14593528, ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}. Cell projection, filopodium tip {ECO:0000269|PubMed:18270267}. Nucleus membrane {ECO:0000269|PubMed:16143324}; Peripheral membrane protein {ECO:0000305}. Note=Co-localizes with OSBPL6 at contact sites between the plasma membrane and the endoplasmic reticulum. {ECO:0000250|UniProtKB:Q9DBS9}. |
| Mouse PG classification | NA |
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