| Gene Information | |
|---|---|
| Gene Name | ORL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 370 |
| Protein Names | Nociceptin receptor (Kappa-type 3 opioid receptor) (KOR-3) (Orphanin FQ receptor) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P41146 |
| Gene Card | OPRL1 |
| Uniprot ID | P41146 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Detected in blood leukocytes. {ECO:0000269|PubMed:7500847}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4EA3 (X-ray 3.01A ) 5DHG (X-ray 3.00A ) 5DHH (X-ray 3.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Note=Ligand binding leads to receptor internalization into cytoplasmic vesicles, decreasing the amount of available receptor at the cell surface. Internalization requires phosphorylation at Ser-363. Can recycle to the cell membrane. |
| Mouse PG classification | NA |
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