| Gene Information | |
|---|---|
| Gene Name | MBD2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 411 |
| Protein Names | Methyl-CpG-binding domain protein 2 (Demethylase) (DMTase) (Methyl-CpG-binding protein MBD2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000134046 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9UBB5 |
| Gene Card | MBD2 |
| Uniprot ID | Q9UBB5 |
| Pfam | PF01429; PF14048; PF16564 |
| In ASD | no |
| Allosteric Prediction | no (-0.474702734) |
| Ortholog in Animals | Alpaca_ MBD2 ( ortholog_one2one ) Dog_ MBD2 ( ortholog_one2one ) GuineaPig_ MBD2 ( ortholog_one2one ) Macaque_ MBD2 ( ortholog_one2one ) Mouse_ Mbd2 ( ortholog_one2one ) Pig_ MBD2 ( ortholog_one2one ) Rat_ Mbd2 ( ortholog_one2one ) Rabbit_ MBD2 ( ortholog_one2one ) |
| Ohnologs | MBD3 |
| Paralogs | MBD1, MBD3L1, MBD3L2B, MBD3L5, MBD3, MBD3L2, MBD3L3, MBD3L4 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in brain, heart, kidney, stomach, testis and placenta. {ECO:0000269|PubMed:10050851}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.223793(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2L2L (NMR - ) 6C1A (X-ray 2.05A ) 6C1T (X-ray 1.84A ) 6C1U (X-ray 2.30A ) 6C1V (X-ray 2.30A ) 6C2F (X-ray 2.65A ) 6CNP (X-ray 2.10A ) 6CNQ (X-ray 2.15A ) 7AO8 (EM 4.50A ) 7AO9 (EM 6.10A ) 7AOA (EM 19.40A ) 7MWK (X-ray 2.45A ) 7MWM (X-ray 1.60A ) 7RAY (X-ray 1.78A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:9774669}. Note=Nuclear, in discrete foci. Detected at replication foci in late S phase. |
| Mouse PG classification | NA |
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