Gene Information
Gene NameORCA
OrganismHomo sapiens (Human)
Gene Length440
Protein NamesSequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBQ13501
Gene CardSQSTM1
Uniprot IDQ13501
PfamPF00564; PF16577; PF00569
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityUbiquitously expressed. {ECO:0000269|PubMed:8650207}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001928(Rat);0.018947(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1Q02  (NMR  -  )  2JY7  (NMR  -  )  2JY8  (NMR  -  )  2K0B  (NMR  -  )  2KNV  (NMR  -  )  4MJS  (X-ray  2.50A  )  4UF8  (EM  10.90A  )  4UF9  (EM  10.30A  )  5YP7  (X-ray  1.42A  )  5YP8  (X-ray  1.45A  )  5YPA  (X-ray  2.50A  )  5YPB  (X-ray  2.90A  )  5YPC  (X-ray  1.96A  )  5YPE  (X-ray  2.85A  )  5YPF  (X-ray  2.95A  )  5YPG  (X-ray  2.20A  )  5YPH  (X-ray  1.63A  )  6JM4  (X-ray  3.20A  )  6KHZ  (X-ray  2.80A  )  6MJ7  (X-ray  1.41A  )  6TGY  (EM  3.50A  )  6TH3  (EM  4.00A  )  7R1O  (X-ray  2.20A  ) 
DBSNP rs1554162295  rs141502868  rs200396166  rs148366738  rs181263868  rs748170760  rs771903158  rs1267306593  rs147810437  rs200152247  rs548787835  rs769325755  rs753212399  rs750256905  rs145056421  rs1582008478  rs201263163  rs761822261  rs765200636  rs151191977  rs1225746517  rs11548633  rs774986849  rs55793208  rs200445838  rs541356917  rs61748794  rs140226523  rs148294622  rs772889843  rs774512680  rs143956614  rs772122047  rs776749939  rs104893941  rs1561609625  rs1247551175  rs771966860  rs143511494  rs757212984  rs770118706  rs199854262 
Subcellular location [CC]Cytoplasm, cytosol {ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:22792322}. Preautophagosomal structure {ECO:0000269|PubMed:34471133}. Late endosome. Lysosome. Cytoplasmic vesicle, autophagosome. Nucleus. Endoplasmic reticulum. Nucleus, PML body {ECO:0000269|PubMed:20168092}. Cytoplasm, myofibril, sarcomere {ECO:0000250}. Note=In cardiac muscle, localizes to the sarcomeric band (By similarity). Commonly found in inclusion bodies containing polyubiquitinated protein aggregates. In neurodegenerative diseases, detected in Lewy bodies in Parkinson disease, neurofibrillary tangles in Alzheimer disease, and HTT aggregates in Huntington disease. In protein aggregate diseases of the liver, found in large amounts in Mallory bodies of alcoholic and nonalcoholic steatohepatitis, hyaline bodies in hepatocellular carcinoma, and in SERPINA1 aggregates. Enriched in Rosenthal fibers of pilocytic astrocytoma. In the cytoplasm, observed in both membrane-free ubiquitin-containing protein aggregates (sequestosomes) and membrane-surrounded autophagosomes. Colocalizes with TRIM13 in the perinuclear endoplasmic reticulum. Co-localizes with TRIM5 in cytoplasmic bodies. When nuclear export is blocked by treatment with leptomycin B, accumulates in PML bodies. {ECO:0000269|PubMed:20168092}.
Mouse PG classificationNA
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