| Gene Information | |
|---|---|
| Gene Name | ORAOV2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 986 |
| Protein Names | Anoctamin-1 (Discovered on gastrointestinal stromal tumors protein 1) (Oral cancer overexpressed protein 2) (Transmembrane protein 16A) (Tumor-amplified and overexpressed sequence 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q5XXA6 |
| Gene Card | ANO1 |
| Uniprot ID | Q5XXA6 |
| Pfam | PF16178; PF04547 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in nasal epithelial cells (at protein level) (PubMed:32487539). In the kidney, expressed in the collecting duct (at protein level) (PubMed:24913262). Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles (PubMed:16906560, PubMed:15215166). Expressed in eccrine sweat glands (PubMed:25220078). {ECO:0000269|PubMed:15215166, ECO:0000269|PubMed:16906560, ECO:0000269|PubMed:24913262, ECO:0000269|PubMed:25220078, ECO:0000269|PubMed:32487539}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs2186797 rs3740722 |
| Subcellular location [CC] | Apical cell membrane {ECO:0000269|PubMed:15215166, ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:21984732, ECO:0000269|PubMed:22178883, ECO:0000269|PubMed:22946059, ECO:0000269|PubMed:28559167, ECO:0000269|PubMed:31732694, ECO:0000269|PubMed:32487539}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8BHY3}. Presynapse {ECO:0000250|UniProtKB:Q8BHY3}. Note=In differentiating airway epithelial cells, predominantly intracellular at day 0 but is apically localized by day 30. Expressed in the presynapse of retinal neurons (By similarity). {ECO:0000250|UniProtKB:Q8BHY3}. |
| Mouse PG classification | NA |
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