| Gene Information | |
|---|---|
| Gene Name | NAPEPLD |
| Organism | Homo sapiens (Human) |
| Gene Length | 393 |
| Protein Names | N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (N-acyl phosphatidylethanolamine phospholipase D) (NAPE-PLD) (NAPE-hydrolyzing phospholipase D) (EC 3.1.4.54) |
| Target Name | n-acyl-phosphatidylethanolamine-hydrolyzing phospholipase d |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000161048 ) 3 ( ENSG00000275723 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q6IQ20 |
| Gene Card | NAPEPLD |
| Uniprot ID | Q6IQ20 |
| Pfam | PF12706 |
| In ASD | yes |
| Allosteric Prediction | no (-0.885345994) |
| Ortholog in Animals | Alpaca_ NAPEPLD ( ortholog_one2one ) Dog_ NAPEPLD ( ortholog_one2one ) GuineaPig_ NAPEPLD ( ortholog_one2one ) Macaque_ NAPEPLD ( ortholog_one2one ) Mouse_ Napepld ( ortholog_one2one ) Pig_ NAPEPLD ( ortholog_one2one ) Rat_ Napepld ( ortholog_one2one ) Rabbit_ NAPEPLD ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Highest expression in brain, kidney and testis (at protein level). Expressed in adipose tissue (at protein level). {ECO:0000250|UniProtKB:Q8BH82}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4QN9 (X-ray 2.65A ) |
| DBSNP | rs12540583 rs3181009 |
| Subcellular location [CC] | Golgi apparatus membrane {ECO:0000269|PubMed:25684574}; Peripheral membrane protein {ECO:0000305|PubMed:25684574}. Early endosome membrane {ECO:0000269|PubMed:25684574}; Peripheral membrane protein {ECO:0000305|PubMed:25684574}. Nucleus envelope {ECO:0000269|PubMed:25684574}. Nucleus, nucleoplasm {ECO:0000269|PubMed:25684574}. Note=Localized in the proximity of the cellular membranes likely through interaction with membrane phospholipids. {ECO:0000269|PubMed:25684574}. |
| Mouse PG classification | NA |
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