| Gene Information | |
|---|---|
| Gene Name | ALOX12B |
| Organism | Homo sapiens (Human) |
| Gene Length | 701 |
| Protein Names | Arachidonate 12-lipoxygenase, 12R-type (12R-LOX) (12R-lipoxygenase) (EC 1.13.11.-) (Epidermis-type lipoxygenase 12) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000179477 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O75342 |
| Gene Card | ALOX12B |
| Uniprot ID | O75342 |
| Pfam | PF00305; PF01477 |
| In ASD | no |
| Allosteric Prediction | no (-0.138964655) |
| Ortholog in Animals | Alpaca_ ALOX12B ( ortholog_one2one ) Dog_ ALOX12B ( ortholog_one2one ) GuineaPig_ ALOX12B ( ortholog_one2one ) Macaque_ ALOX12B ( ortholog_one2one ) Mouse_ Alox12b ( ortholog_one2one ) Pig_ ALOX12B ( ortholog_one2one ) Rat_ Alox12b ( ortholog_one2one ) Rabbit_ ALOX12B ( ortholog_one2one ) |
| Ohnologs | ALOX15 |
| Paralogs | ALOX12, ALOX15, ALOXE3, ALOX5, ALOX15B |
| Tissue | skin, tongue, zone.of.skin, lower.leg.skin, suprapubic.skin |
| Tissue Specificity | Expressed in B-cells, hair follicles, foreskin keratinocytes and adult skin. Also expressed in psoriatic tissue. {ECO:0000269|PubMed:9618483}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs201575829 rs397514533 rs8077661 rs397514526 rs72842957 rs200516538 rs1567981916 rs760428119 rs1039399607 rs137853023 rs774958790 rs763468558 rs199766569 rs199545653 rs137853024 rs752509098 rs397514528 |
| Subcellular location [CC] | Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00726}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:9837935}. |
| Mouse PG classification | NA |
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