| Gene Information | |
|---|---|
| Gene Name | EPHB3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 998 |
| Protein Names | Ephrin type-B receptor 3 (EC 2.7.10.1) (EPH-like tyrosine kinase 2) (EPH-like kinase 2) (Embryonic kinase 2) (EK2) (hEK2) (Tyrosine-protein kinase TYRO6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000182580 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P54753 |
| Gene Card | EPHB3 |
| Uniprot ID | P54753 |
| Pfam | PF14575; PF01404; PF07699; PF00041; PF07714; PF00536 |
| In ASD | no |
| Allosteric Prediction | no (-0.124107921) |
| Ortholog in Animals | Alpaca_ EPHB3 ( ortholog_one2one ) Dog_ EPHB3 ( ortholog_one2one ) GuineaPig_ EPHB3 ( ortholog_one2one ) Macaque_ EPHB3 ( ortholog_one2one ) Mouse_ Ephb3 ( ortholog_one2one ) Pig_ EPHB3 ( ortholog_one2one ) Rat_ Ephb3 ( ortholog_one2one ) Rabbit_ EPHB3 ( ortholog_one2one ) |
| Ohnologs | EPHB6, EPHA1, EPHB4, EPHA8, EPHA4, EPHB2, EPHA2, EPHB1, EPHA10 |
| Paralogs | EPHA7, NTRK1, ALK, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, PDGFRA, EGFR, CSF1R, ERBB3, KIT, NTRK3, DDR1, ERBB4, EPHA8, TEK, MUSK, MERTK, FGFR4, FLT3, EPHB6, FLT1, DDR2, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, ERBB2, KDR, EPHA5, FGFR2, TYRO3, MST1R, AXL, EPHB2, ROR1, ROR2, ROS1, EPHA10, EPHA4, RET, LTK, FLT4, TIE1, FGFR1, RYK, EPHA1, MET |
| Tissue | pancreas |
| Tissue Specificity | Ubiquitous. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3P1I (X-ray 2.10A ) 3ZFY (X-ray 2.20A ) 5L6O (X-ray 1.88A ) 5L6P (X-ray 2.26A ) |
| DBSNP | rs56029711 rs56103851 rs56129875 rs371378866 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:15536074}; Single-pass type I membrane protein {ECO:0000269|PubMed:15536074}. Cell projection, dendrite {ECO:0000250}. |
| Mouse PG classification | NA |
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