Gene Information
Gene NameMARCH2
OrganismHomo sapiens (Human)
Gene Length246
Protein NamesE3 ubiquitin-protein ligase MARCHF2 (EC 2.3.2.27) (Membrane-associated RING finger protein 2) (Membrane-associated RING-CH protein II) (MARCH-II) (RING finger protein 172) (RING-type E3 ubiquitin transferase MARCHF2)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBQ9P0N8
Gene CardMARCHF2
Uniprot IDQ9P0N8
PfamPF12906
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityBroadly expressed. {ECO:0000269|PubMed:14722266}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs1133893  rs34099346 
Subcellular location [CC]Endoplasmic reticulum membrane {ECO:0000269|PubMed:14722266};
Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5I0I2}. Lysosome membrane {ECO:0000269|PubMed:14722266};
Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:23166351};
Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5I0I2}. Golgi apparatus membrane {ECO:0000269|PubMed:23818989};
Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:32935379}. Cell membrane {ECO:0000269|PubMed:32935379};
Multi-pass membrane protein {ECO:0000269|PubMed:32935379}.
Mouse PG classificationNA
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