| Gene Information | |
|---|---|
| Gene Name | TLR5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 858 |
| Protein Names | Toll-like receptor 5 (Toll/interleukin-1 receptor-like protein 3) |
| Target Name | toll-like receptor 5 |
| Target Type | Clinical trial target |
| Gene Age | 8 ( ENSG00000187554 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O60602 |
| Gene Card | TLR5 |
| Uniprot ID | O60602 |
| Pfam | PF13855; PF01582 |
| In ASD | no |
| Allosteric Prediction | yes (0.298899337) |
| Ortholog in Animals | Alpaca_ TLR5 ( ortholog_one2one ) Dog_ TLR5 ( ortholog_one2one ) Macaque_ TLR5 ( ortholog_one2one ) Mouse_ Tlr5 ( ortholog_one2one ) Pig_ TLR5 ( ortholog_one2one ) Rat_ Tlr5 ( ortholog_one2one ) |
| Ohnologs | TLR4, TLR2 |
| Paralogs | CD180, RXFP1, TLR8, NRROS, TSKU, TLR7, TLR10, RXFP2, TLR6, LRRC3B, IGFALS, TLR3, TLR2, TLR4, LRRC17, LRRC32, LRRC53, VASN, TLR1, LRRC3C, LRRC3, LRIT2 |
| Tissue | NA |
| Tissue Specificity | Highly expressed on the basolateral surface of intestinal epithelia (PubMed:11489966). Expressed also in other cells such as lung epithelial cells (PubMed:11489966, PubMed:18490781). {ECO:0000269|PubMed:11489966, ECO:0000269|PubMed:18490781}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3J0A (EM 26.00A ) |
| DBSNP | rs764535 rs5744166 rs5744167 rs45528236 rs2072493 rs5744174 rs5744175 rs56243703 rs7512943 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:24778236}; Single-pass type I membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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