| Gene Information | |
|---|---|
| Gene Name | TNFRSF18 |
| Organism | Homo sapiens (Human) |
| Gene Length | 241 |
| Protein Names | Tumor necrosis factor receptor superfamily member 18 (Activation-inducible TNFR family receptor) (Glucocorticoid-induced TNFR-related protein) (CD antigen CD357) |
| Target Name | activation-inducible tnfr family receptor |
| Target Type | Clinical trial target |
| Gene Age | 987 ( ENSG00000186891 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9Y5U5 |
| Gene Card | TNFRSF18 |
| Uniprot ID | Q9Y5U5 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.289835129) |
| Ortholog in Animals | Alpaca_ TNFRSF18 ( ortholog_one2one ) Dog_ TNFRSF18 ( ortholog_one2one ) GuineaPig_ TNFRSF18 ( ortholog_one2one ) Macaque_ TNFRSF18 ( ortholog_one2one ) Mouse_ Tnfrsf18 ( ortholog_one2one ) Pig_ TNFRSF18 ( ortholog_one2one ) Rat_ Tnfrsf18 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TNFRSF25, TNFRSF6B, CD40, TNFRSF21, TNFRSF1A, TNFRSF10C, TNFRSF11B, TNFRSF10B, TNFRSF11A, CD27, NGFR, FAS, TNFRSF10A, TNFRSF9, TNFRSF8, LTBR, RELT, TNFRSF10D, TNFRSF4, TNFRSF14, TNFRSF1B |
| Tissue | skin, lower.leg.skin, suprapubic.skin |
| Tissue Specificity | Expressed in lymph node, peripheral blood leukocytes and weakly in spleen. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.003490(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7KHD (X-ray 2.96A ) 7LAW (X-ray 2.75A ) |
| DBSNP | rs11466676 rs11466687 rs11466688 rs11466693 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted. |
| Mouse PG classification | NA |
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