| Gene Information | |
|---|---|
| Gene Name | VASH1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 365 |
| Protein Names | Tubulinyl-Tyr carboxypeptidase 1 (EC 3.4.17.17) (Tubulin carboxypeptidase 1) (Tyrosine carboxypeptidase 1) (TTCP 1) (Vasohibin-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000071246 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q7L8A9 |
| Gene Card | VASH1 |
| Uniprot ID | Q7L8A9 |
| Pfam | PF14822 |
| In ASD | no |
| Allosteric Prediction | no (-1.461342339) |
| Ortholog in Animals | Alpaca_ VASH1 ( ortholog_one2one ) Dog_ VASH1 ( ortholog_one2one ) GuineaPig_ VASH1 ( ortholog_one2one ) Macaque_ VASH1 ( ortholog_one2one ) Mouse_ Vash1 ( ortholog_one2one ) Pig_ VASH1 ( ortholog_one2one ) Rat_ Vash1 ( ortholog_one2one ) Rabbit_ VASH1 ( ortholog_one2one ) |
| Ohnologs | VASH2 |
| Paralogs | VASH2 |
| Tissue | NA |
| Tissue Specificity | Preferentially expressed in endothelial cells (PubMed:15467828, PubMed:16707096). Highly expressed in fetal organs (PubMed:15467828). Expressed in brain and placenta, and at lower level in heart and kidney (PubMed:15467828). Highly detected in microvessels endothelial cells of atherosclerotic lesions (PubMed:16707096). {ECO:0000269|PubMed:15467828, ECO:0000269|PubMed:16707096}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002990(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6J4U (X-ray 2.00A ) 6J7B (X-ray 1.62A ) 6J8F (X-ray 2.28A ) 6J8N (X-ray 1.95A ) 6J8O (X-ray 1.85A ) 6J91 (X-ray 3.50A ) 6J9H (X-ray 2.31A ) 6K81 (X-ray 2.28A ) 6LPG (X-ray 2.30A ) 6NVQ (X-ray 2.10A ) 6OCF (X-ray 2.10A ) 6OCG (X-ray 1.83A ) 6OCH (X-ray 2.00A ) 6WSL (EM 3.10A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15467828, ECO:0000269|PubMed:27879017}. Secreted {ECO:0000269|PubMed:15467828, ECO:0000269|PubMed:16707096, ECO:0000269|PubMed:20736312, ECO:0000269|PubMed:27879017}. Note=Mainly localizes in the cytoplasm (PubMed:27879017). Some fraction is secreted via a non-canonical secretion system; interaction with SVBP promotes secretion (PubMed:27879017). {ECO:0000269|PubMed:27879017}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |